Validity of two common asthma-specific quality of life questionnaires: Juniper mini asthma quality of life questionnaire and Sydney asthma quality of life questionnaire (original) (raw)
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Development and validation of the mini asthma quality of life questionnaire
2001
The 32-item Asthma Quality of Life Questionnaire (AQLQ) has shown good responsiveness, reliability and construct validity; properties that are essential for use in clinical trials, clinical practice and surveys. However, to meet the needs of large clinical trials and long-term monitoring, where efficiency may take precedent over precision of measurement, the 15-item self-administered MiniAQLQ has been developed. The MiniAQLQ was tested in a 9-week observational study of 40 adults with symptomatic asthma. Patients completed the MiniAQLQ, the AQLQ, the Short Form (SF)-36, the Asthma Control Questionnaire and spirometry at baseline, 1, 5 and 9 weeks. In patients whose asthma was stable between clinic visits, reliability was very acceptable for the MiniAQLQ (intraclass correlation coefficient (ICC)=0.83), but not quite as good as for the AQLQ (ICC=0.95). Similarly, responsiveness in the MiniAQLQ (p=0.0007) was good but not quite so good as for the AQLQ (p<0.0001). Construct validity (correlation with other indices of health status) was strong for both the MiniAQLQ and the AQLQ. Criterion validity showed that there was no bias between the instruments (p=0.61) and the correlation between them was high (r=0.90). The Mini Asthma Quality of Life Questionnaire has good measurement properties but they are not quite as strong as those of the original Asthma Quality of Life Questionnaire. The choice of questionnaire should depend on the task at hand.
Measuring asthma-specific quality of life: structured review
Allergy, 2011
Measuring quality of life (QoL) has become an increasingly important dimension of assessing patient well-being and drug efficacy. As there are now several asthma QoL questionnaires to choose from, it is important to appreciate their strengths and weaknesses. To assist in this choice, we have reviewed the existing questionnaires in a structured way. Information relating to the conceptual and measurement model, reliability, validity, interpretability, burden, administration format and translations was extracted from the published literature. The instruments differ in almost all criteria considered, and therefore it cannot be assumed that they measure the same thing. We recommend the selection of questionnaires that are designed only for asthma and that do not assess symptoms as part of QoL. Only two of the questionnaires reviewed fulfill these requirements: the Sydney Asthma QoL Questionnaire (AQLQ-S) and the Living with Asthma Questionnaire (LWAQ). However, for multinational studies, it may be convenient or practical to use questionnaires that have been linguistically validated in many languages (AQLQ-J, SGRQ). It remains unclear which of these questionnaires best reflects patient perceptions of QoL. Our review did not involve patients, so for the time being choosing from existing questionnaires requires a compromise based on the rigor of the development process and the target patient group.
Validity of three asthma-specific quality of life questionnaires: the patients' perspective
BMJ open, 2016
It is not known which of the many asthma-specific quality of life (QoL) questionnaires best capture the lived experience of people with asthma. The objective of this study was to explore patients' views of three commonly used asthma-specific QoL questionnaires. Qualitative study using semistructured interviews. Primary and secondary care in Brighton and Hove, UK. 30 adult people with a physician-diagnosis of asthma who were asked to complete the Juniper Asthma Quality of Life Questionnaire (AQLQ-J), the Sydney Asthma Quality of Life Questionnaire (AQLQ-S) and the Living with Asthma Questionnaire (LWAQ) to elicit their views on the content validity of these. Thematic content analysis revealed a lack of congruence between the concerns of people with asthma and the questionnaire content in terms of missing (eg, allergies) and irrelevant (eg, smoky restaurants) content. The AQLQ-J was perceived as a 'narrow', 'medical' questionnaire focused on symptoms, the environme...
Asthma and Health-Related Quality of Life
Allergology International, 2005
The health-related quality of life (HRQoL) is assessed using instruments that have been validated scientifically. From the viewpoint of assessment, they are different from other clinical indices because the subjects themselves evaluate their own HRQoL (the patients in many clinical settings). As an index for evaluating health care services or outcomes, the HRQoL is as important as life expectancy. These instruments can be classified into generic and disease-specific instruments. There are numerous disease-specific instruments that can be used for patients with asthma, such as Juniper et al .'s Asthma Quality of Life Questionnaire (AQLQ), the Living with Asthma Questionnaire (LWAQ), the St. George's Respiratory Questionnaire (SGRQ) , and Marks et al .'s Asthma Quality of Life Questionnaire (AQLQ). The characteristics of each instrument should be considered in the selection of specific HRQoL questionnaires for clinical research. Generally, the HRQoL is more disturbed in patients with severe asthma, and has been considered to be an important end-point in randomized controlled trials that involve asthma patients. We expect that further studies will also be performed in Japan
A scale for assessing quality of life in adult asthma sufferers
Journal of Psychosomatic Research, 1991
The Asthma Questionnaire is a 68-item quality of life scale designed to be sensitive to quality of life changes in clinical trials. The questionnaire covers 11 domains of life experience, the initial domain and item sets being derived from six qualitative focus groups of asthma patients. Psychometric analysis of responses of I01 asthma patients to the initial 10 l-item set showed the scale to be unidimensional despite being multi-domain, and the finding of unidimensionality was replicated during the further three stages of item refinement using 783 patients. The scale compensates for acquiescence bias as well as allowing a 'not applicable' response category. Validity of the scale was demonstrated by confirmation of expected group differences and the retest reliability was 0.948.
Validation of the asthma impact survey, a brief asthma-specific quality of life tool
Quality of Life Research, 2007
Background: The Asthma Impact Survey (AIS-6) is a new six question asthma outcome tool for which information on validity has not been published. Objective: To provide validation for the AIS-6 as a brief asthma-specific quality of life tool. Methods: Surveys were sent to a random sample of members of a large managed care organization who were at least 35 years of age and in the two-year period preceding the survey had either (1) at least one documented asthma-related medical encounter, or (2) at least a 6 months supply of asthma medication dispensed. In addition to the AIS-6, the survey included a validated quality of life tool [the mini-Asthma Quality of Life Questionnaire (AQLQ)]; a validated asthma control questionnaire [the Asthma Therapy Assessment Questionnaire TM (ATAQ)]; a validated symptom severity scale (AOMS); and information regarding demographics, co-morbidities, asthma severity, and asthma management. The results of the AIS-6 were compared to the results of the other tools by means of correlation and factor analysis. Independent predictors of AIS-6 and AQLQ scores were determined by multiple stepwise linear regression analyses. Results: AIS-6 scores were significantly related to female sex, educational level, income, smoking, body mass index (BMI), COPD, steroid use, and hospitalization history in bivariate analyses. The AIS-6 score significantly correlated (r = ) 0.84, p < 0.0001) with the AQLQ total score and loaded on the three factors (activity, symptoms, and concern/ bother) reflected by the survey information and on which the AQLQ also loaded. Significant but somewhat smaller correlations were found between the AIS-6 and the ATAQ (r = 0.70, p < 0.0001) and the AOMS (r = 0.55, p < 0.0001). Independent predictors were the same for the AIS-6 and AQLQ and included oral steroid use, COPD history, BMI, female sex, educational level, and hospitalization in the past year. Conclusion: These data support the validity of the short six-question AIS-6 as an asthmaspecific quality of life tool.
Quality-of-life and asthma-severity in general population asthmatics: results of the ECRHS II study
Allergy, 2008
Many studies conducted both in clinical and populationbased samples show that the quality-of-life is impaired in asthmatic patients (1-3). One of the major goals in the management of asthma is to improve the health-related quality-of-life (HRQL) of patients. Standardized questionnaires, either generic applied over all diseases or specific for asthma, have been developed in tandem with clinical criteria to measure the impact of the disease on daily life in clinical trials (4, 5). Results from Juniper et al. (6) indicated that HRQL measures add complementary information to conventionally-used clinical outcomes. There are few data on HRQL in asthmatics selected from community-based samples and determinants of HRQL remain poorly addressed. Although the quality-of-life decreased with the degree of asthma-severity (7, 8), HRQL is not simply a further index of severity, as the degree to which disease is perceived to affect daily life may vary between patients with the same asthma-severity.
Living with Asthma Questionnaire
1991
The 'Living with Asthma Questionnaire' is an asthma-specific quality of life scale for assessing patients' own subjective experiences of asthma. The purpose of the questionnaire is to assist individual patient management and to provide an outcome measure for use in clinical trials. The scale has 68 items and covers 11 domains of asthma experience which were derived from focus group discussions amongst asthma sufferers. The initial item set was refined through standard psychometric techniques using a total of 783 patients and there is no statistical evidence for independent, domain-specific subscales. Validation studies are described.
Journal of clinical epidemiology, 1999
We performed analyses to examine the structure, validity, and responsiveness to change of the Marks Asthma Quality of Life Questionnaire (AQLQ), originally validated in Australia in a self-administered format, among 539 U.S. subjects with asthma. Subjects were interviewed twice by telephone over an 18-month period. Based on factor analyses, the subscale structure of the AQLQ was modified slightly to eliminate item overlap among subscale scores. Cross-sectionally, total AQLQ scores were significantly correlated in expected directions with baseline asthma severity scores (r = 0.58), SF-36 physical (r = -0.66) and mental (r = -0.40) health status scores, and pulmonary function (FEV1% predicted, r = -0.14). Longitudinally, changes in AQLQ total and subscale scores were significantly (P<0.01) associated with changes in asthma severity and both physical and mental status. The AQLQ, administered by telephone, appears to be useful for assessing changes in the impact of adult asthma.