Nutritional, Sensory Evaluation and Biological Effect on diabetic rats of Cakes Enhanced with Pumpkin Fruit and Its Seeds (original) (raw)
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This study was aimed to evaluate the hypoglycaemic, hypolipidemic and liver protective effects of pumpkin and sunflower seeds powder in male diabetic rats. A total of 24 rats were randomized into 4 groups of 6 each as follows: Group 1: Normal control; Group 2: Diabetic control; Group 3: Diabetics administered with pumpkin seeds powder (3%); Group 4: Diabetics administered with sunflower seeds powder (3%). The rats were made diabetic by alloxan (100 mg/kg body weight (BW)) injection and were treated until blood glucose reach to above 200 mg/dl. Blood samples were collected following the experiment. Liver specimens were also collected for histological analysis. Glucose, cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, ALT activity, AST activity were significantly increased, while total protein and albumin were decreased in diabetic rats as compared to the normal control group. Pumpkin and sunflower seeds significantly decreased glucose, cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, ALT activity, AST activity as compared to diabetic group. Therefore, pumpkin and sunflower seeds might be beneficial in diabetic patients.
Anti-diabetic and hypoglycemic properties of fibre-enriched cake in alloxan-induced diabetic rats
Mediterranean Journal of Nutrition and Metabolism, 2012
Studies have provided evidence of the hypoglycemic properties of fiber-containing foods compared to fiber-free foods. In this study, the hypoglycemic properties and beneficial effects of fiber-enriched cake in alloxaninduced diabetic rats were reported. Diabetes was induced by a single intraperitoneal injection of alloxan. Fiberenriched cake was produced from selected fruits and fed to the treatment group. The rats were monitored daily for food intake, and body weight. Their blood glucose levels were monitored on weekly basis. Treatment lasted for 14 days, after which the rats were sacrificed by cervical dislocation. Blood was collected by cardiac puncture and centrifuged to obtain serum which was analyzed to evaluate serum insulin level. Histological study was carried out on the pancreatic tissues. There was no significant difference in diet intake and body weight among the experimental groups. Feeding on the formulated cake led to 68.75 % reduction of the blood glucose level compared to the diabetic group.
Journal of Diabetes and …, 2010
Reactive oxygen species play a crucial role in the pathogenesis of diabetes and its complications. This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. Animals were allocated into three groups of six rats each: a control group (CD), diabetic group (DD) and diabetic rats fed with flax and pumpkin seed mixture (DMS) group. The diabetic rats (DD) presented a significant increase in glycemia, plasma and liver lipid parameters such as total lipid, total cholesterol and triglycerides compared to the control group (CD). In addition, plasma and liver malonaldialdehyde levels (MDA, an index of lipid peroxidation) significantly increased compared to (CD). Antioxidant enzymes activities such as catalase, superoxide dismutase, and reduced glutathione (GSH) levels significantly decreased in the plasma and liver of diabetic rats compared to controls. Diet supplemented with flax and pumpkin seed mixture in the DMS group ameliorated antioxidant enzymes activities and level of GSH in diabetic rats and significantly decreased MDA levels. The present study revealed a significant increase in the activities of aspartate aminotransferase and alanine aminotransferase on diabetic status, indicating considerable hepatocellular injury. The administration of flax and pumpkin seed mixture attenuated the increased levels of the plasma enzymes produced by the induction of diabetes and caused a subsequent recovery towards normalization comparable to the control group animals. Our results thus suggest that flax and pumpkin seed mixture supplemented to diet may be helpful in preventing diabetic complications in adult rats.
Food Science and Technology, 2024
Pumpkin, soybean, cinnamon and morel berry have the potential as functional foods for people with diabetes. Therefore, this research aimed to determine the effect of pumpkin instant porridge formula plus extract on the pancreatic beta-cell repair of the diabetic mice lipid profile induced by alloxan. A total of 7 groups of mice (Mus musculus) strain DDY (Deutschland Denken and Yoken) Japan were grouped as positive control K(+) (diabetic mice), including the group that was given FA porridge (instant porridge group with 120 mg/kg body weight (WB) extract), FB (addition of 240 mg/kg BW extract), FC (addition of 360 mg/kg BW extract), FD (addition of 480 mg/kg BW extract), FE (addition of 600 mg/kg BW extract), and OG Group (Glibenclamide drug). The formula was given for 30 days, starting when the mice had diabetes (fasting blood glucose level ≥126 mg/dL). The histopathological description of the mice pancreas in the instant porridge group improved pancreatic tissue with a decrease in cells undergoing necrosis. The observations of lipid performance also showed a significant effect between several treatments for total and HDL cholesterol levels (p<0.05). However, the lipid profile performance of mice with instant porridge did not significantly affect cholesterol levels. The finding indicated that giving pumpkin instant porridge plus cinnamon and morel berry extract can act as a functional food to improve lipid profiles in people with diabetes.
This study was aimed to evaluate the hypoglycaemic and hypolipidemic effects of different doses of pumpkin (Cucurbita pepo L.) powder in male diabetic rats. A total of 35 rats were randomized into 5 groups of 7 each as follows: Group 1: Normal control; Group 2: Diabetic control; Group 3: Diabetics administered with low doses of pumpkin powder (1 g/kg); Group 4: Diabetics administered with high doses of pumpkin powder (2 g/kg), and Group 5: Diabetics administered with glibenclamide (0.6 mg/kg), as positive control. The rats were made diabetic by alloxan (120 mg/kg body weight (BW)) injection and were treated for 4 weeks on a daily basis. Blood samples were collected following the experiment. Pancreatic specimens were also collected for histological analysis. Glucose, cholesterol, triglycerides, low density lipoprotein (LDL) and C-reactive protein (CRP) were significantly increased, while insulin was decreased in diabetic rats as compared to the normal control group (p < 0.05). Low dose pumpkin significantly decreased glucose, triglycerides, LDL and CRP as compared to diabetic group and high dose pumpkin decreased cholesterol (p < 0.05). Histological analysis also revealed a significant increase in the diameter and number of langerhans islets in treated group with pumpkin, which was consistent with the latter findings. Therefore, pumpkin might be beneficial in diabetic patients.
Hematological and biochemical changes in diabetic rats fed with fiber-enriched cake
Journal of Acute Medicine, 2013
Background: There have been emerging interests in functional foods, which fall in the gray area between conventional foods and medicine, over the years owing to their health benefits. In this study, the effect of fiber-enriched cake, produced from selected fruits, on the hematology and serum biochemistry of diabetic rats was investigated. Materials and methods: Diabetes was induced by an intraperitoneal injection of alloxan. Treatment lasted for 14 days, after which the rats were sacrificed humanely. Blood was collected by cardiac puncture and some of it was centrifuged to obtain serum. The serum was analyzed to evaluate alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, creatinine, urea, albumin, and lipid profiles. The uncentrifuged blood was analyzed for hematological profile. Results: The rats fed on the cake had increased levels of red blood cells, hemoglobin, packed cell volume, red blood cells, and platelets compared to the untreated diabetic rats. Elevated levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, creatinine, urea, and albumin were observed in the diabetic rats; this was significantly reduced in the cake-fed group. Induction of diabetes led to increased levels of cholesterol, low-density lipoprotein, and triglyceride, and a low level of high-density lipoprotein. These results were significantly reversed, except for the triglyceride level, in the cake-fed group. Conclusion: These results indicate the potentials of the fiber-enriched cake as a functional food with a therapeutic effect against hematological and biochemical changes associated with diabetes mellitus. Consequently, such a cake can serve as an adjunct to dietary therapy for diabetes.
Effect of using sweet potato powder on diabetic rats
مجلة الاقتصاد المنزلی
The main aim of this research was to study the influence of sweet potato powder on diabetic rats. A total of 24 adult male albino rats of "Sprague Dawley" strain (150 ±5g) were used and randomly divided into 4 equal groups including negative control group, positive control group, while the other two groups were treated with 10% raw potato and 30% cooked potato depending on sensory evaluation of biscuits supplemented with raw and cooked sweet potato powder. The experiment lasted for 28 days. Measurements included determining glucose, liver functions, kidney functions and lipid profile in serum and pancreas histopathology. The results indicated that induced alloxan resulted in significant increases in glucose in urine and serum, in addition to a significant increase in liver and kidney functions, lipid profile expect HDL-C were decreased compared with a negative control group and abnormal histopathological changes were noticed in pancreas dysfunction resulted from abnormal histopathology was observed. Like raw and cooked sweet potato induced anti-diabetic effects and decreased glucose in blood serum. Moreover, they alleviated alloxan-induced abnormalities in body weight, liver and kidney functions. Accordingly, this study recommends diabetic patients to regularly consume sweet potato and its leaves with a suitable dose since they can induce an improvement in increase blood sugar.
Bioscience, Biotechnology, and Biochemistry, 2009
The effects of a pumpkin paste concentrate and its components on oral glucose tolerance and serum lipid levels were determined in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. In the oral glucose tolerance test, the pumpkin paste concentrate-fed group maintained a lower glucose level than the control group between 15 and 60 min. The compounds considered to be effective in improving glucose tolerance and contained in the methanol extract of the pumpkin in relatively abundant amounts were isolated and identified as trigonelline (TRG) and nicotinic acid (NA). Feeding a diet containing TRG and NA respectively improved and tended to improve glucose tolerance. The insulin level increased after 15 min in the TRG-fed GK rats and then gradually decreased over the next 120 min. In contrast, a gradual increase was seen in the insulin level over 120 min in the control GK rats not fed with TRG, suggesting that TRG could improve the insulin resistance. The serum and liver triglyceride (TG) levels in the TRG-and NA-fed GK rats were lower than those in the control GK rats. Lower activity of liver fatty acid synthase (FAS), and higher activity of liver carnitine palmitoyl transferase (CPT) and glucokinase (GLK) in the TRG-and NA-fed GK rats than in the control GK rats were observed. This suggests that the regulation of these enzyme activities by TRG and NA was closely related to the suppression of both TG accumulation and the progression of diabetes.
Study on the anti-diabetic properties of functional foods: A review
Study on the anti-diabetic properties of functional foods: A review, 2024
The number of diabetic populations is increasing with much higher rate than predicted by various research authorities from various countries. Such drastic peak in diabetic population observed could be to changing lifestyle and unhealthy eating habits of majority of population. Mortality rates concerning with diabetes mellitus are higher in low-income countries due to lack of medical care and infrastructure. Diabetes mellitus is more dangerous when it invites other related complications like organ damage, retina and kidney damage, cardiovascular diseases and lack in the efficiency of nervous system. Various medicines are available which can administer orally or intravenously. These medications are efficient in reducing blood glucose levels of the body but in the same time they send signals to nervous system to stop the production of insulin permanently over a period of time as insulin is available in enough amounts from external sources. People tend to become dependent over medications for life time. In recent times, awareness regarding the clinical benefits of natural foods have been observed among researchers in order to treat diseases like diabetes mellitus and numerous natural foods which are antidiabetic in nature. These foods inhabit hypoglycaemic compounds which helps in reducing blood glucose levels and trigger the production of insulin naturally. This study focuses on nutritional aspects, in-vitro and in vivo studies conducted on pumpkin, flaxseeds and oats specifically, in order to prove their hypoglycaemic effect on human body. The exact mechanism and pathways behind this hypoglycaemic effect is difficult to establish, still few researches have predicted the most probable mechanism and pathways which have been discussed.