373: Can pregnancy associated complications predict primary atherothrombotic occlusive vascular events in premenopausal women? (original) (raw)

2007

Abstract

THROMBOTIC OCCLUSIVE VASCULAR EVENTS IN PREMENOPAUSAL WOMEN? GALIA ORON, YARIV YOGEV, SHLOMIT BEN-AMI, AVI BEN-HAROUSH, MOSHE HOD, JACOB BAR, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqwa, and Sackler Faculty of Medicine, Tel Aviv University, Obstetrics and Gynecology, Tel Aviv, Israel OBJECTIVE: Scarcity of data exists concerning the potential association between pregnancy complications as early risk factor for atherothrombotic event. The aim of this study was to determine if adverse pregnancy outcomes can be added to the list of classical risk factors for atherothrombotic occlusive vascular disease (AOVD), in young women. STUDY DESIGN: A retrospective questionnaire/case-control study. Study group included women aged 50 years with an ICD-9 diagnosis of AOVD (a documented primary cerebrovascular, myocardial, or peripheral arterial ischemic events) who were treated between 1995 to 2004. Classical risk factors for AOVD and aspects of pregnancy outcome were compared with healthy women matched individually for age, parity and body mass index. RESULTS: 1. Overall, 101 women with AOVD were identified, of them; 53 had a myocardial ischemic event, 33 a cerebrovascular event, and 15 a peripheral ischemic arterial event. 2. On multivariate analysis, in addition to the known risk factors for AOVD (diabetes, hypertension, dyslipidemia and family history of vascular disease) intrauterine growth restriction was found to be an independent risk factor for development of AOVD (O.R 8.41, 95% C.I 2.36-29.9, p 0.001). 3. Women with more than one of the following pregnancy complication (GDM, PET, spontaneous preterm delivery, placental abruption, or fetal loss) were at increased risk for more than one arterial occlusive event (O.R 13.71, 95% C.I 1.56-120.39, p 0.02). CONCLUSION: Intrauterine growth restriction and multiple pregnancy complications are independent, early risk factor for subsequent AOVD in pre-menopausal women

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