Palladium/tetraphosphine catalyzed suzuki cross-coupling of heteroarylboronic acids with aryl halides (original) (raw)

Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C 3 H 5)] 2 efficiently catalyses the Suzuki reaction of heteroarylboronic acids with aryl bromides and also the coupling of arylboronic acids with heteroaryl bromides. The coupling of thiophene-or benzothiopheneboronic acids, furan-or benzofuranboronic acids and 3-pyridineboronic acid with a variety of aryl bromides gave the corresponding coupling products in good yields. However, in most cases, better results in terms of ratio substrate/catalyst were obtained for the reverse reaction using heteroaryl bromides with arylboronic acids.