Bio-catalysts and catalysts based on ruthenium(II) polypyridyl complexes imparting diphenyl-(2-pyridyl)-phosphine as a co-ligand (original) (raw)

Reactions of the ruthenium complexes [Ru(k 3 -tpy)(PPh 3 )Cl 2 ], [Ru(k 3 -tptz)(PPh 3 )Cl 2 ] and [Ru(k 3 -tpy)Cl 3 ] [tpy ¼ 2,2 0 :6 0 ,2 00 -terpyridine; tptz ¼ 2,4,6-tris(2-pyridyl)-1,3,5-triazine] with diphenyl-(2-pyridyl)-phosphine (PPh 2 Py) have been investigated. The complexes [Ru(k 3 -tpy)(PPh 3 )Cl 2 ] and [Ru(k 3 -tptz)(PPh 3 )Cl 2 ] reacted with PPh 2 Py to afford [Ru(k 3 -tpy)(k 1 -P-PPh 2 Py) 2 Cl] þ (1) and [Ru(k 3 -tptz)(k 1 -P-PPh 2 Py) 2 Cl] þ (2), which were isolated as their tetrafluoroborate salts. Under analogous conditions, [Ru(k 3 -tpy)Cl 3 ] gave a neutral complex [Ru(k 3 -tpy)(k 1 -PPh 2 Py)Cl 2 ] (3). Upon treatment with an excess of NH 4 PF 6 in methanol, 1 and 2 gave [Ru(k 3 -tpy)(k 1 -P-PPh 2 Py)(k 2 -P,N-PPh 2 Py)](PF 6 ) 2 ( ) and [Ru(k 3 -tptz)(k 1 -P-PPh 2 Py)(k 2 -P,N-PPh 2 Py)](PF 6 ) 2 (5) containing both monodentate and chelated PPh 2 Py. Further, 4 and 5 reacted with an excess of NaCN and CH 3 CN to afford [Ru(k 3 -tpy)(k 1 -P-PPh 2 Py) 2 (CN)](PF 6 ) ( ), [Ru(k 3 -tpy)(k 1 -P-PPh 2 Py) 2 (NCCH 3 )](PF 6 ) 2 ( ), [Ru(k 3 -tptz)(k 1 -P-PPh 2 Py) 2 (CN)]PF 6 ( ) and [Ru(k 3 -tptz)(k 1 -P-PPh 2 Py) 2 (NCCH 3 )](PF 6 ) 2 ( ) supporting hemi labile nature of the coordinated PPh 2 Py. The complexes have been characterized by elemental analyses, spectral (IR, NMR, electronic absorption, FAB-MS), electrochemical studies and structures of 1, 2 and 3 determined by X-ray single crystal analyses. At higher concentration level (40 mM) the complexes under investigation exhibit inhibitory activity against DNA-Topo II of the filarial parasite S. cervi and 3 catalyses rearrangement of aldoximes to amide under aerobic conditions.