The Helicobacter pylori genome evolution in different gastric cancer risk Colombian populations (original) (raw)

Background The Helicobacter pylori (H. pylori) has evolved with its human host by nearly 110,000 years. Despite that H. pylori has been considered as a main factor for gastric cancer (GC) development, the pathogenesis depends on its hosts evolutive relations. Objective In this study we analyzed the H. pylori evolutive relations of two populations with different GC risk in Colombia. Materials and Methods We study 10 human genomes and same number of H. pylori genomes from Tuquerres: high GC risk population, and 9 genomes from Tumaco: low GC risk population. The evolutive analysis was performed using MLST, vacA virulence gene and alpA adhesine gene for H. pylori and human ancestry by phylogenomic analyzes. Results We found that the studied people from Tumaco had marked African and Amerindian ancestry and in minor proportion European ancestry. In contrast, the studied human population from Tuquerres had mainly Amerindian and European ancestry. The H. pylori phylogenomic trees from Tumac...

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