In Vitro Properties of Solid Lipid Microparticles (SLMS) Loaded with Methanolic Extract of Garcinia Kola (Heckel) Seed (original) (raw)

2013

Abstract

Objective: The decline in the use of herbal medicine especially in the Western world may be due to lack of readily available market brand formulations and the fact that most herbal remedies are taken as tea, decoctions and infusions. The taste of some of these herbal drugs is not palatable, and some have unpleasant odour and colour hence, the need to formulate these drugs in form of encapsulated dosage forms. The objective of the work was to formulate solid lipid microparticles (SLMs) loaded with the methanolic extract of Garcinia kola seed. Methods: The SLMs containing 1 and 3 % of Garcinia kola seed extract were formulated using fat from Capra hircus and Phospholipon ® 90H (3:1). The particle morphology and size, encapsulation efficiency (EE%), pH, in vitro release and the inhibition zone diameter (IZD) of the SLMs were determined. Results: The results showed that the extract was very bitter while, the encapsulated G. kola had slight bitter taste. The pH remained in the acidic reg...

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