Ekspresi cyclooxygenase-2 (COX-2) pada penderita rinosinusitis kronis (original) (raw)
Oto Rhino Laryngologica Indonesiana
Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, which are closely related to the involvement of ostiomeatal complex as the drainage pathway of of maxillary and frontal sinuses. Inflammation or edema at the ostiomeatal complex could cause drainage problems leading to rhinosinusitis. Increased expression of COX-2 regulation was considered to play an important role in the development of CRS and increased airway inflammation in the nasal mucosa and paranasal sinuses. Purpose: To find out the expression of Cyclooxygenase-2 in our CRS patients. Methods: This descriptive research was conducted on July 2011 - December 2011 at ENT Department and Pathology Anatomy Department of Medical Faculty of Sumatera Utara University/H. Adam Malik General Hospital, Medan, to all patients diagnosed with CRS and underwent sinus surgery on July 2011 - December 2011. Results: The highest proportion of pain in patients with CRS is facial pain/pressure an...
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