Portal Hypertension in the Liver Cirrhosis : Physiopathology and Therapeutical Approach of Esophageal Variceal Bleeding (original) (raw)

Portal hypertension represent the major consequence of liver cirrhosis, with lifethreatening complications like upper digestive hemo rrhage through esophageal varices efraction. The physiopathology of portal hypertensi o in chronic liver disease is dominated by two factors, portal blood inflow and i ntrahepatic vascular resistance, which are responsible for the hemodinamic changes i n portal venous system. The main complication of portal hypertension is eso phageal and gastric varices development, and therefore the standard of care sho uld be focused primarly on prophylaxy and secondly, in advanced cases, on vari ce l bleeding treatment. We describe here the physiopathology of portal hype rtension in cirrhosis, as well as the current management of the most important and potentially catastrophic complication, acute variceal bleeding.

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