Hepato-curative effects of crude phenol root extract of soddom of apple (C. Procera) on CCL₄ induced hepatotoxicity in albino rats (original) (raw)

Bayero Journal of Pure and Applied Sciences

Traditional medicine is the oldest form of health care in the world and is used in the prevention and treatment of physical and mental illnesses. Different societies historically developed various useful healing m combat a variety of mild and life diseases. Traditional Medicine known as complementary and alternative ethnic medicine, and it still plays a key role in many countries today (Haidan et al., Calotropis procera is a wild growing tropical plant which possesses various medicinal properties. C. Procera belongs to the family Asclepiacea (milkweed family) of the Genus Calotropis R. Br. (Calotropis). procera or Giant milkweed is also known as sodom apple, calotrope, French cotton, small crown flower (English), Tumfafiya (hausa), Epuko (Nupe), Common names; auricular tree, dead sea apple, swallow-wort, apple gian-milk weed, madar mudar, ruberbush, s ABSTRACTS The effects of phenol root extracts of C. procera and livolin on liver function indices of CCl induced hepatotoxicity was evaluated on forty (40) albino rats. The animals were grouped into four (I, II, III and IV) of 10 rats each, 120mg/kg of CCl II, III, and IV intramuscularly followed by oral administration of root extract of C. procera to group III and IV respectively. Analysis of variance (ANOVA) for multiple comparisms test were used to compare the result of the liver and kidney biochemical parameters from the test and control group The hepatic biochemical markers Alanine Aminotransferase (ALT), Aspartate Amino Transferases (AST), Alkaline Phosphatases (ALP) of the toxicant group (Gp II) were significantly higher (P<0.001), while group III (treated w (P<0.05) when compared with control (Gp I), this confirms the toxicity and treatment with livolin respectively. Oral administrations of the extracts at 10 days exposure lower all the liver function markers and increase indication of the hepatocurative effect of the extract against CCl 20 days exposure the activities of the liver markers were raised. The Histopathological photomicrograph showed moderate cytolysis and karyolysis.