Potential combination therapy using twenty phytochemicals from twenty plants to prevent SARS- CoV-2 infection: An in silico Approach (original) (raw)
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2021
Recently identified coronavirus namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded positive-sense RNA virus with a genome of 29.9 kb in size encoding 14 open reading frames (ORFs) and 27 different structural and non-structural proteins. Among the structural proteins, trimeric-shaped spike glycoprotein is responsible for the entry of the SARS-CoV2 genome into host cells by interacting with human angiotensin-converting enzyme 2 (ACE2) receptors that are present on the cell surface with high affinity. Notably, inhibition of spike protein is considered a prime target for the development of drugs against COVID-19. Viruses can mutate, and SARS-CoV-2 is no exception. Since the first whole genome of SARS-CoV2 was published in February 2020, at least 4400 amino acid substitutions and several thousand mutations have been identified to date. As of today, more than 3500 new variants of SARS-CoV2 have been sequenced with a high spreading and infectivity rate...
Evaluation of some plant-derived natural ingredients against SARS-CoV-2: An in-silico approach
International Journal of Phytocosmetics and Natural Ingredients
Background The first epidemic of 2019 was burst out in December when novel coronavirus (SARS-CoV-2, severe acute respiratory syndrome coronavirus 2) took place in Wuhan city, China. 1,2 Since the outbreak, it has been rapidly infecting people around the world and turned into a pandemic. The virus conserves significant phylogenetic and structural familiarity (about 80% nucleotide identity and 89.10% nucleotide similarity) with the SARS-CoV. 3,4 Therefore, it has been named SARS-CoV-2 and has been placed in the same lineage. 5 Vaccines are under development, and to date, there is no permanent solution to eradicate the pandemic from the world. The transmission rate of the virus is massive worldwide, and hence all researchers over the world are keenly looking forward to the effective compounds that could act as anti-CoV therapeutic agents.
Molecules
The novel pathogenic virus was discovered in Wuhan, China (December 2019), and quickly spread throughout the world. Further analysis revealed that the pathogenic strain of virus was corona but it was distinct from other coronavirus strains, and thus it was renamed 2019-nCoV or SARS-CoV-2. This coronavirus shares many characteristics with other coronaviruses, including SARS-CoV and MERS-CoV. The clinical manifestations raised in the form of a cytokine storm trigger a complicated spectrum of pathophysiological changes that include cardiovascular, kidney, and liver problems. The lack of an effective treatment strategy has imposed a health and socio-economic burden. Even though the mortality rate of patients with this disease is lower, since it is judged to be the most contagious, it is considered more lethal. Globally, the researchers are continuously engaged to develop and identify possible preventive and therapeutic regimens for the management of disease. Notably, to combat SARS-CoV-...