Ovarian hyperstimulation syndrome: are preventive measures effective? (original) (raw)

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Ovarian hyperstimulation syndrome (OHSS) represents a significant complication arising from ovulatory treatments in assisted reproduction. This analysis explores the pathophysiology of OHSS and emphasizes the importance of identifying risk factors for its prevention. While effective therapeutic methods do not exist, a range of preventive strategies, including modified administration of gonadotropins and careful monitoring of hormonal levels, show promise in minimizing the incidence and severity of OHSS in at-risk populations.

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Ovarian hyperstimulation syndrome (OHSS)-our clinical experience

2015

Introduction: Ovarian hyperstimulation syndrome (OHSS) is a serious complication of the luteal phase/early pregnancy, usually iatrogenic, after ovulation induction or ovarian hyperstimulation in the context of intrauterine insemination and in vitro fertilization (IVF). It is usually a self limiting disorder but may be more severe and persist longer than usual, if pregnancy is successful. Renal and hepatic dysfunction, thrombosis, hydrothorax, cerebral infarct and adult respiratory distress syndrome (ARDS) are the leading causes of morbidity and mortality seen in severe cases. Materials and methods: This is a retrospective study of two years which included women with clinical signs and symptoms suggestive of OHSS. Diagnosis was confirmed by the investigations. Conservative medical management was the main stay of treatment with daily monitoring of the clinical and biochemical parameters. Surgical management like paracentesis, pleuracentesis, diagnostic laparoscopy and therapeutic term...

Ovarian hyperstimulation syndrome. The new approaches for diagnosis, treatment and prevention

2015

Ovarian hyperstimulation syndrome (OHSS) is the most serious consequence of induction of ovulation, as part of assisted conception techniques. Although the ultimate physiologic mechanism of OHSS is not yet known, there are well-known risk factors that must be considered during the administration of medications to treat infertility. The clinical course of OHSS may involve, according to its severity and the occurrence of pregnancy, electrolytic imbalance, neurohormonal and hemodynamic changes, pulmonary manifestations, liver dysfunction, hypoglobulinaemia, febrile morbidity, thromboembolic phenomena, neurological manifestations and adnexal torsion. Specific approaches such as paracentesis, pleural puncture, surgical approach of OHSS and specific medication during OHSSwere evaluated sporadically. Moreadequate treatment methods wouldrequire abetter understanding of the underlying pathophysiological mechanisms, to promote an etiopathogenic therapeutic approach. The following review aims ...

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