A whole genome association study of neuroticism using DNA pooling (original) (raw)
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Archives of General Psychiatry, 2008
Classical genetic study designs such as family and twin studies provide evidence for familial aggregation and the magnitude of genetic component. Furthermore, linkage studies map susceptible regions for diseases. Genomic regions that are identified by linkage analyses are likely to contain genes influencing one disorder or including pleiotropic loci and can then be targeted for more extensive gene identification, namely candidate gene association study. Due to the rapid advances in genotyping technology, genome-wide association studies (GWAS) with hundreds of thousands of markers are now becoming popular. The GWAS is a hypothesis free method which densely genotypes SNPs (single nucleotide polymorphism) and CNVs (copy number variations) along the whole genome without prior hypotheses of candidate genes for the diseases. These large scale genetic studies offer great promise to expedite the discovery of the common genetic variants affecting common diseases or traits of interest. In the recent few years, the GWAS has demonstrated to be a successful strategy because there have been multiple successes with the identification of highly compelling candidate genes, such as age-related macular degeneration, body mass index, inflammatory bowel disease, and type 2 diabetes mellitus.
A genome-wide association study of neuroticism in a population-based sample
2010
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire.
Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci
2015
Neuroticism is a personality trait of fundamental importance for psychological wellbeing and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes and heterogeneity in the measurement of neuroticism. Here we report a genome-wide association study of neuroticism in 91,370 participants of the UK Biobank cohort and a combined meta-analysis which includes a further 6,659 participants from the Generation Scotland Scottish Family Health Study (GS:SFHS) and 8,687 participants from a QIMR Berghofer Medical Research Institute (QIMR) cohort. All participants were assessed using the same neuroticism instrument, the Eysenck Personality Questionnaire-Revised (EPQ-R-S) Short Form Neuroticism scale. We found a SNP-based heritability estimate for neuroticism of approximately 15% (SE = 0.7...