Nutritional and medicinal potential of Lagenaria siceraria (original) (raw)
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Antibiotics in current use are losing efficacy due to microbial resistance. New anti-infectious agents are required. Lagenaria siceraria (Molina) Standley is known for its diverse therapeutic effects. The study assessed antimicrobial efficacy of its pedicles to determine if they contain novel, natural, effective, and safe antimicrobial drugs. Zones of inhibition (ZOIs) and minimum inhibitory concentrations (MICs) were determined using agar well diffusion and agar dilution methods, respectively. A number of microorganisms were tested. The methanolic extract (ME) showed potency against Achromobacter xylosoxidans, Pseudomonas aeruginosa, and Citrobacter freundii with ZOIs of 17.5, 16.5, and 15.0 mm, respectively. For comparison, the ZOIs produced by amoxicillin, at the same concentration (40 mg∙mL˗1 ), against these microbes were 40.0, 16.5, and 16.0 mm, respectively. The ME also exhibited potency against Bacillus megaterium, Stenotrophomonas maltophilia, Klebsiella pneumoniae, Enterobacter cloacae, and Enterobacter aerogenes. The most susceptible strains were selected for evaluation against fractions of ME. The ethyl acetate fraction was the most potent with ZOIs against A. xylosoxidans, B. megaterium, P. aeruginosa, and C. freundii of 18.0, 16.0, 16.0, and 15.0 mm, respectively. A. xylosoxidans was the most susceptible bacterium. The MICs of the ethyl acetate fraction, against different bacteria, ranged from 0.08 to 0.32 mg∙mL˗1 . The pedicles of L. siceraria fruit could be a potential source for new antibiotics against a variety of microorganisms.
Current Nutrition & Food Science
Lagenaria siceraria, commonly known as bottle gourd, is extensively grown in India and other tropical and sub-tropical regions of the world. The bottle gourd is rich in a number of phytoconstituents, minerals, vitamins, fibre etc. with potent neutraceutical and therapeutic functions. Leaves and roots are used as emetic to reduce baldness and to relieve headache. Flowers are used as antidote in certain kinds of poisons. L. siceraria is reported to exhibit cardioprotective, antihyperlipidemic, antioxidant, antihyperglycemic, analgesic, anti-inflammatory, immunomodulatory and hepatoprotective functions in human subjects as well as in experimental models. The bottle gourd is proved to be a potential source of prophylactic and therapeutic neutraceuticals and can serve as 'medicinal food' particularly in metabolic disorders associated with carbohydrate and lipid metabolisms. The objective of this article is to review the ethnopharmacological and other medicinal applications of L. siceraria along with phytochemical and biochemical composition.
Medicinal and nutritional importance of Lagenaria siceraria (Lauki)
Saudi Journal of Biomedical Research, 2022
Lagenaria siceraria (Lauki) belong to the Cucurbitaceae family. It is also known as calabash or white flowered gourd and locally kado. There are 118 general and 825 species. It is found in many countries Pakistan, India, Sri-Lanka, and Africa. The fruit is the rich source of the ascorbic acid, beta carotene and a good source of vitamin B complex. The seeds of L. siceraria contain amino acids, proteins, lignin, and iron. The leaves contain carbohydrates, phytoestrols, saponins, phenolic compounds, tennis, proteins, amino acids and flavonoids. Lagenaria siceraria seed oil has cooling effects and can be applied in migraine type headache. The fruit of the L. siceraria help to reduce the inflammation on the liver and the juice of the L. siceraria on empty stomach in morning is the best remedy liver disease, heart disease, urinary problems and depression. The juice also helps to change the concentration of the urea and uric acid in kidney. The fruit is used for the treatment of the jaundi...
Frontiers in Nutrition
Since ancient times, the Cucurbitaceae family is used as a therapeutic option in human medicine. This family has around 130 genera and 800 species. Researchers have studied the various plants of this family including Lagenaria siceraria due to their medicinal potential. Various properties are beneficial for human health, that have been attributed to L. siceraria like antioxidant, hypolipidemic, diuretic, laxative, hepatoprotective, analgesic, antihypertensive, cardioprotective, central nervous system stimulant, anthelmintic, free radical scavenging, immunosuppressive, and adaptogenic. The fruit of this plant is commonly used as a vegetable that has a low-calorie value. The species possess a diverse set of biological compounds like flavonoids, sterols, saponins, and terpenoids. Vitamins, choline, flavonoids, minerals, proteins, terpenoids, and other phytochemicals are also found in the edible parts of this plant. Besides 17 different amino acids, many minerals are reported to be pres...
Bottle gourd (Lagenaria siceraria) belongs to the family Cucurbitaceae, which comprises about 118 genera and 825 species. It is an important vegetable crop of India, and its production is influenced by a number of factors viz., environmental, nutritional, cultural operation and use of plant growth regulators. Since, bottle gourd belongs to a medicinal family, it plays a major role in the treatment of several diseases related to the skin and heart. There are several organic chemical compounds including vitamin B complex, pectin, dietary soluble fibres, ascorbic acid, beta-carotene, amino acids and minerals which have been isolated from this species. Therefore, the bottle gourd is considered to have a great impact on therapeutic health benefits. Due to drastic industrialization and urbanization, most of the human beings are facing several ill effects which may lead to death at extreme cases. Hence, the major research area was said to be nanotechnology. Taking into consideration, we have combined nanotechnology field with waste source in the name of green synthesis and planned to cure several diseases, as most of the researchers focused their work on this and succeeded too. The present study is a complete review of L. siceraria that covers the ethnomedical uses, chemical constituents, and pharmacological profile. This study is mainly focused on the antibacterial, hepatoprotective, diuretic and anthelminthic activities.
Medicinal value of Lagenaria siceraria: An overview
2017
Cucurbitaceae family is major source of medicinal agents since ancient time. Various plants parts including fruits of this family have been established for their pharmacological potential. Different parts (leaves, stem, flower, root, seeds and even whole plant) of Lagenaria siceraria (known as lauki in Hindi), has been used in the ointment for ailment of various diseases throughout India. The fruit of cultivated Lagenaria siceraria is the good source of different nutrients components like protein, fat, fibre, carbohydrates, calcium, magnesium. The plant has also been suggested to possess antioxidant activity, laxative, cardioprotective, diuretic, hepatoprotective, hypolipidemic, central nervous system stimulant, anthelmintic, antihypertensive, immunosuppressive analgesic, adaptogenic and free radical scavenging activity. Boiled in oil this pulp is used to treat rheumatism and insomnia. A wide range of chemical compounds including sterols, terpenoids, flavonoids and saponins have bee...
Phytochemical and Pharmacological Profile of Lagenaria Siceraria : An Overview
2012
Cucurbitaceae family is major source of medicinal agents since ancient time. Various plants parts including fruits of this family have been established for their pharmacological potential. Lagenaria siceraria (Molina) standley (family Cucurbitaceae) commonly known as lauki (Hindi) and bottle gourd (English) is a medicinal plant. It is used as medicine in India, China, European countries, Brazil, Hawaiian island, etc. for its cardiotonic, general tonic and diuretic properties. Further the antihepatotoxic, analgesic and anti-inflammatory, hypolipidemic, antihyperglycemic, immunomodulatory and antioxidant activities of its fruit extract have been evaluated. It is used as vermifuge purgative diuretic and it is also recommended for increasing lactation for lactating women.Fruits are also used in treatment of cancer, pain, ulcer, fever, pectoral cough, asthma and other bronchial disorders. In many countries, this plant has been used traditionally as a single treatment for diabetes mellitu...
A Review on Pharmacognostical and Pharmacological Activities of Lagenaria siceraria Species
International Journal of Pharmacology, Phytochemistry and Ethnomedicine, 2015
The Cucurbitaceae family consists of about 735 species. The present study includes detailed aspects of species of Lagenaria siceraria(Mol.) Standley is a medicinal plant. The plant mainly contains carbohydrates, protein, fats and amino acids. The active constituent of Lagenaria is cucurbitacin, lagenin and various mineral matters. In most of the countries lagenaria has been used as antioxidant, cardiotonic, liver tonic, anti-inflammatory, diuretic, antihepatotoxic, antitumor, anti HIV, anti proliferative agent. Thus, lagenaria posses broad spectrum of pharmacological activities. Moreover, the entire plant and its parts like fruit, fruit pulp, seeds, epicarp etc. shows medicinally important properties. This review article focuses on the pharmacognostic, phytochemistry and pharmacological profile of Lagenaria.