Honey and cancer: A mechanistic review (original) (raw)

Clinical Nutrition

Abstract

BACKGROUND Globally, cancer ranks among the most common causes of death. Multiple experimental and clinical studies have investigated anticancer effects of honey with promising results. This study focused on potential background mechanisms of this effect. METHODS The current literature was reviewed for potential anticancer pathways which are suggested for honey and its ingredients. RESULTS Flavonoids (kaempferol, catechin, and quercetin) and phenolic acids (caffeic acid and gallic acid) are the most important ingredients of honey with known anti-cancer activity. The main suggested mechanisms for anti-cancer activity of honey and its ingredients are antioxidant, apoptotic, tumor necrosis factor inhibiting, antiproliferative, immunomodulatory, anti-inflammatory and estrogenic effects. CONCLUSION This review collates the current scientific understanding on the mechanism of anti-cancer activity of honey.

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