DBS and the Treatment of Obsessive Compulsive Disorder (original) (raw)

Abstract

sparkles

AI

This research investigates the efficacy of deep brain stimulation (DBS) in treating patients with treatment-resistant obsessive-compulsive disorder (OCD). The study highlights the clinical significance of electrical stimulation in the anterior limbs of the internal capsules, demonstrating substantial decreases in OCD symptom severity and improvements in mood among severely affected patients. Although promising results were observed, current technical limitations necessitate further research and a structured approach to ensure safety and efficacy before broader application of this treatment.

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

References (18)

  1. Rasmussen SA, Eisen JL. The epidemiology and clinical features of obsessive compulsive disorder. Psychiatric Clin North Am 1992; 15: 743-758
  2. Rasmussen SA, Eisen JL. Clinical and epidemiologic find- ings of significance to neuropharmacologic trials in OCD. Psychopharmacol Bull 1988; 24: 466-470
  3. Zitterl W, Demal U, Aigner M, Lenz G, Urban C, Zapotoczky HG, et al. Naturalistic course of obsessive compulsive dis- order and comorbid depression. Longitudinal results of a prospective follow-up study of 74 actively treated patients. Psychopathology 2000; 33: 75-80
  4. Rauch SL. Neuroimaging and neurocircuitry models per- taining to the neurosurgical treatment of psychiatric dis- orders. Neurosurg Clin North Am 2003; 14: 213-223
  5. Modell JG, Mountz JM, Curtis GC, Greden JF. Neurophy- siologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 1989; 1: 27-36
  6. Jenike MA. Neurosurgical treatment of obsessive-compul- sive disorder. Br J Psychiatry 1998; 35 (Suppl): 79-90
  7. Albucher RC, Curtis GC, Pitts K. Neurosurgery for obsessive- compulsive disorder: problems with comorbidity. Am J Psy- chiatry 1999; 156: 495-496
  8. Irle E, Exner C, Thielen K, Weniger G, Ruther E. Obsessive- compulsive disorder and ventromedial frontal lesions: clinical and neuropsychological findings. Am J Psychiatry 1998; 155: 255-263
  9. Rasmussen SA, Tsuang MT. The epidemiology of obsessive compulsive disorder. J Clin Psychiatry 1984; 45: 450-457
  10. Mindus P. Present-day indications for capsulotomy. Acta Neurochirurgica 1993; 58 (Suppl): 29-33 61
  11. Nuttin BJ, Gabriels LA, Cosyns PR, Meyerson BA, Andree- witch S, Sunaert SG, et al. Long-term electrical capsular stimulation in patients with obsessive-compulsive disorder. Neurosurgery 2003; 52: 1263-1272; discussion 1272-1274
  12. Litofsky NS, Chin LS, Tang G, Baker S, Giannotta SL, Apuzzo ML. The use of lobectomy in the management of severe closed-head trauma. Neurosurgery 1994; 34: 628-632; discussion 632-633
  13. Nuttin BJ, Gabriels L, van Kuyck K, Cosyns P. Electrical stimu- lation of the anterior limbs of the internal capsules in pa- tients with severe obsessive-compulsive disorder: anecdotal reports. Neurosurg Clin North Am 2003; 14: 267- 274
  14. OCD-DBS Collaborative Group. Deep brain stimulation for psychiatric disorders. Neurosurgery 2002; 51: 519
  15. Schuurman PR, Bosch A, Bossuyt PMM, Bonsel GJ, Van Someren EJW, de Bie RMA, et al. A comparison of continu- ous thalamic stimulation and thalamotomy for suppression of severe tremor. NEJM 2000; 342: 461-468
  16. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR, et al. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry 1989; 46: 1012-1016
  17. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleisch- mann RL, Hill CL, et al. The Yale-Brown Obsessive Compul- sive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989; 46: 1006-1011
  18. Gabriels L, Cosyns P, Nuttin B, Demeulemeester H, Gybels J. Deep brain stimulation for treatment-refractory obsessive- compulsive disorder: psychopathological and neuropsy- chological outcome in three cases. Acta Psychiatrica Scand 2003; 107: 275-282