In Vitro Antioxidant and Anti-HIV Activity of Endophytic Coumarin from Crotalaria pallida Aiton (original) (raw)
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Journal of Fundamental and Applied Sciences, 2018
Endophytic fungi that reside in plant tissues are a potential source of secondary metabolites with biological activities. In our study, we investigated the detection of the antioxidant activity of the crude fungal extract of the genera Cladosporium, Alternaria, Aspergillus and Penicillium: endophytic fungi isolated from the leaves of Peganum harmala harvested in Laghouat and extract of these same leaves. The extraction of these metabolites was carried out using ethyl acetate. The antioxidant activity of the latter was carried out by the DPPH test. Our tests reveal that the extracts studied have a low antioxidant activity. The inhibitory concentrations show a higher antioxidant effect for the Penicillium extract compared to the other extracts studied. The antioxidant molecules are related to the content of polyphenols. Penicillium extract has the highest polyphenol content. Our results confirm that endophytic fungi are a potential and limited source of natural antioxidant compounds, in the same way as plants.
2020
Description of the subject: current investigative work is focused on the search for new antioxidant molecules of natural origin, to counter the damage that oxidative stress can cause and to propose therapeutic alternatives. Objective: the objective of this study is to relate the traditional use of Myrtus communis L. and Rhamnus alaternus L. by the population of Boumerdes and their antioxidant activity. Methods: the demonstration of the antioxidant power of the two plants consists of a phytochemical screening allowing to have an idea on the presence or the absence of certain primary and secondary metabolites. The antioxidant activity is evaluated by the method of reduction of iron on the three acetone, methanolic and ethanolic extracts. Results: phytochemical screening reveals a wealth of both plants in polyphenols, glucosides, saponosides, reducing sugars and flavonoids with an absence of catechic tannins, anthocyanins, carotenoids, irridoids, proteins, sterols, polyterpenes, starch...
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Essential oils are frequently used for flavour and fragrance in the perfume, pharmaceutical, cosmetic and food industries. The antibacterial activity of the essential oil of Origanum compactum was tested (in solid and liquid media) against 16 clinical isolates. This oil showed a higher antibacterial activity against strains resistant to antibiotics. Résumé : L'huile essentielle d'Origanum compactum est testée, en milieux solide et liquide, pour son activité antibactérienne contre 16 souches bactériennes isolées de malades souffrant pour la plupart d'infections urinaires. Cette huile a témoigné d'une forte action antibactérienne même vis à vis de souches multirésistantes aux antibiotiques.
The essentials oils of the leave of Ageratum conyzoïdes, Eucalyptus citriodora, Cymbopogon nardus and Clausena anisata extracted by internment to steam are tested on some bacterias. The oils of Clausena anisata have the better action again all the bacterias. The GC and GC-SM are used to identify the chemical component. The oil of Clausena anisata and Ageratum conyzoïdes contained much hydrocarbon compounds. The volatile oils of Eucalyptus citriodora and Cymbopogon nardus in oxygen compounds.
Chemical composition and antimicrobial activity of Croton urucurana Baillon (Euphorbiaceae)
Journal of Ethnopharmacology, 1997
In the methanolic extract of Croton urucurana Baillon (Euphorbiaceae) a number of known compounds, such as acetyl aleuritolic acid, stigmasterol, β-sitosterol, campesterol, β-sitosterol-O-glucoside, sonderianin, catechin and gallocatechin were isolated and identified by MS and NMR spectroscopy, HRGC and data from literature. The antibacterial activity of the aqueous–EtOH extract, some fractions of the methanolic extract and some of the isolated compounds,
Activités antioxydantes de dix plantes medicinales de la pharmacopée ivoirienne
Le stress oxydant, cause de plusieurs maladies, suscite la recherche de nouveaux remèdes antioxydants. Dans cette optique, l'étude de l'activité antioxydante des extraits méthanoliques de dix (10) plantes utilisées dans la pharmacopée ivoirienne a été réalisée. Ces plantes sont issues de la région forestière de la Côte d'Ivoire et précisément du département d'ISSIA (région du haut Sassandra). Les extraits des dix plantes sont obtenus après macération dans le méthanol 96 %, pendant 48 H, à la température ambiante (25°C), suivie d'une double filtration sur coton puis sur papier wattman 3 mm et évaporé au rotavapor. La poudre ainsi obtenue, nous a permis de réaliser nos tests phytochimiques et antioxydants. Le tri phytochimique, l'activité antiradicalaire par le DPPH et l'inhibition de la peroxydation lipidique par la méthode au thiocyanate ferrique et la méthode des TBARS ont été utilisées. Le tri phytochimique a permis de révéler que ces plantes contiennen...
Many of the current research interest include the study of molecular antioxidant compounds of natural source. This study aims to evaluate the antioxidant activities of the methanolic extracts of different parts of Detarium microcarpum: trunk and root bark, leaves, fruits and flowers. The total polyphenol content was determined by the Folin-Ciocalteu method and the antioxidant activity by two methods: the free radical scavenging of the DPPH and the Ferric reducing antioxidant power (FRAP) method. The total polyphenol content of plant parts was found to vary from 109.44 to 40.06 mg gallic acid equivalents per gram of extract (mg EAG/g). Iron reduction capacity was found to be highest in the trunk bark (171.71 mole EAA/100mg); root (170.79 mole EAA/100mg) and leaves (127.96 mole EAA/100mg) extracts. The DPPH scavenging capacity showed a significant reduction of the DPPH radical with IC50 inhibitory concentrations ranging from 0.225 to 0.75 mg/ml but still remain low compared to that of Trolox asstandard antioxydant. The antioxidant activities of Detarium microcarpum extracts reported in this study could justify the traditional uses of this plant in order to develop new bioactive compounds.
The high cost of fungicides, the international markets standards for agricultural product quality, the environmental issues and consumer health discourage to the application of chemical control. The strategy is therefore to develop alternative solutions, less expensive and addresses environmental concerns. This study was conducted to evaluate the fungicidal potency of Crotalaria retusa L. on Phytophthora sp. and Fusarium solani, two phytopathogenic fungi. This plant was selected after an ethnobotanical study conducted in the sub-prefecture of Lauzoua in Côte d'Ivoire. It is considered to be the most widely used in the treatment of microbial diseases. The phytochemical screening of this legume species was carried out, and showed the presence of saponosides, sterols, tannins, alkaloids, flavonoids, polyphenols, quinones and polyterpenes. The sensitivity of these two phytopathogenic fungi strains was tested in vitro in presence of the aqueous extract of Crotalaria retusa L. by using double dilution method on PDA medium (Potato Dextrose Agar). The minimum inhibitory concentration