Transplacental Teratogenic and Carcinogenic Effects in Rabbits Chronically Treated With N-Ethyl-N-nitrosourea 1.2.3 (original) (raw)

2016

Abstract

ABSTRACT-Pregnant rabbits of two partially inbred strains. WH/J and IIIVO/J. were given ten consecutive daily ip injections of 10 mg N-ethyl-N-nitrosourea (ENU)/kg dissolved In trioctanoin starting on either day 10. 15. or 18 of gestation. Of 7 WH/J progeny weaned. 3 developed primary renal tumors at 6.8±0.6 months of age (mean ± SE). Similarly. of 12 IIiVO/J progeny weaned. 10 developed primary renal tumors at 6.3±0.6 months of age (mean ± SE); in addition. 1 fibroblastic osteosarcoma and 5 neurofibromas. some associated with neurilemma cysts. were observed. Renal tumors were nephroblastomas. which appeared to develop within small renal cortical cysts. The frequency of tumor induction for each strain was similar to that in our previous experiments with acute administration of ENU and ethyl-urea plus NaN0 2 • but the latency period (6.4±0.5 mol was almost doubled. In addition. chronic treatment of ENU induced terato-

R. Pottathil hasn't uploaded this paper.

Let R. know you want this paper to be uploaded.

Ask for this paper to be uploaded.