Genetic and inflammatory bowel disease(IBD): is there a relationship between polymorphisms of hMLH1 gene and different subtype of ulcerative colitis (UC)? (original) (raw)

This study investigates the relationship between polymorphisms of the hMLH1 gene and different subtypes of ulcerative colitis (UC). The research involved 42 unrelated UC patients, analyzing their DNA for polymorphisms. The findings indicate a higher prevalence of pancolitis and clinically active disease in patients with certain hMLH1 gene mutations, particularly in the homozygous group. Additionally, an examination of late pouch-anal fistulas post-surgery revealed an incidence of 5.1%, with conservative management being preferred for complications.