CDK5RAP2 Gene and Tau Pathophysiology in Late-Onset Sporadic Alzheimer’s Disease (original) (raw)

Alzheimer's & Dementia

Abstract

that results in increased amyloid beta levels. Results:We will report our results and discuss how they relate to the relationship between these mutations and both chemokine and amyloid beta levels in mammalian cell lines. Conclusions: This work will allow us to examine the role that amyloid beta plays in the activation of pro-inflammatory responses by the chemokine receptors CCBP2 and CCLR2 and their respective mutants. This work could lead to a means of regulating amyloid beta production and expression which could lead to novel therapeutic solutions.

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