Ion Mobility-Mass Spectrometry of Protonated Molecules―Intramolecular Proton Transfer by Bimolecular Reaction― (original) (raw)

Laser-Driven Proton Acceleration and Beam-Transport

The Review of Laser Engineering, 2012

Laser-driven proton beam attracts many fields of potential applications because of its peculiar characteristics. However, in order to apply, for example, to the medical application, we need to increase the energy of the proton beam. We have been trying to increasing the energy of the laser-driven proton beam at JAEA. We established the beam transport line by using the beam optics of the conventional accelerator for the laser-driven MeV proton beam and have made beam transport test.

Nanomechanics of Surface Immobilized Protein Molecules

Hyōmen kagaku, 2001

Proteins and polypeptides were first covalently immobilized on a solid surface and then extended by a tensile force applied at the two ends of the polymer chain. The method consisted of introducing cysteine residues at N-and C-termini of protein molecules and covalently immobiling them on an amino-silanized surface of a crystalline silicon wafer. The other end of the protein molecule was cross-linked to a functionalized AFM (atomic force microscope) tip with covalent cross-linkers. The relationship between the tensile force and the extension length of the molecule was measured using the force curve mode of AFM. Results obtained with a polyglutamic acid that takes helical conformation in acidic and random coil state in neutral and alkaline media is described. Also the relationships measured with β-sheet globular protein, carbonic dehydratase are given.