A Novel Drug Delivery System: Niosomes Review (original) (raw)

Niosomes : as novel vesicular drug delivery system

2018

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Noisome are promising vehicle for drug delivery and being non-ionic, more stable, inexpensive, biodegradable, biocompatible, non immunogenic and exhibit flexibility in their structural characterization. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various c...

Novel drug delivery system for the vesicular delivery of drug by the niosomes

Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of non-ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. Drug delivery system using colloidal particulate carrier such as liposomes or niosomes has distinct advantages over conventional dosage forms because the particles can act as drug containing reservoirs. Modification of the particle composition or surface can adjust the affinity for the target site and/or the drug release rate. Niosomes proved to be a promising drug carrier and has potential to reduce the side effects of drugs and increased therapeutic effectiveness in various diseases.

A Review on Niosomes: Potential Vesicular Drug Delivery System

Journal of Drug Delivery and Therapeutics

Over the years researchers have been making an attempt to improve the potency of utilization of medicament for treatment of numerous diseases. During this endeavour, drug delivery systems have helped greatly by achieving reduced dose, reduced dosage frequency, improved patient compliance, improved bioavailability and maximum concentration of the drug at the target site. Recent years have seen an unprecedented growth in the use of nanotechnology in designing drug delivery systems. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, comparatively non-toxic, stable, economical and effective alternate to liposomes. This review is deepening and widening the interest of Niosomes in several scientific disciplines and notably its application in drug delivery. This review additionally presents a summary of the types, methods of preparation, characterization and applications of Niosomes. Keywords: Niosomes, types, method of preparation, factors affecting and app...

Niosomes: A Review Of Drug Delivery System

International Journal of Pharmaceutical Sciences, 2024

In the past few years, there has been a significant change in the way infectious disease management and vaccination practices are carried out. With the development of biotechnology and genetic engineering, numerous biologicals targeted at certain diseases have been developed; additionally, the efficient distribution of these biologicals has received attention. Comparatively speaking, niosomes are less expensive, more stable, nontoxic, and biodegradable than liposomes because they are made of non-ionic surfactants. However, they are more stable than liposomes during the production and storage processes. This paper examines the recent surge in interest in niosomes across several scientific fields, with a focus on medical applications. A thorough overview of niosome types, characterization, applications, and preparation methods is also given in this article.

Non-Ionic Surfactant Vesicles (Niosomes) as New Drug Delivery Systems

Novel Approaches for Drug Delivery

Lipid vesicular systems composed of hydrated amphihiles with or without bilayer inducing agents such as cholesterol. On the basis of used amphiphilic molecule different nomenclature are used as liposomes, ufasomes and niosomes. Nonionic surfactants with mono-, di- or trialkyl chains form niosomes which are lipid vesicles with more chemical stability in comparison with phospholipids of liposomes. Both hydrophobic and hydrophilic chemicals can be encapsulated in niosomes as a new drug delivery system. This drug carrier system could have administered via injection, oral, pulmonary, vaginal, rectal, ophthalmic, nasal or transdermal routes with penetration enhancing potential. This chapter presents a detailed explain about niosome forming components, methods of preparation and routes of administration. Many examples for drug delivery potential of niosomes are also available in this review. Vaccine adjuvant and genetic substances vector capabilities are not given here.

An Overview Of Niosomes-Novel Strategies For Drug Delivery

International Journal in Pharmaceutical Sciences, 2023

For novel drug delivery of drug is required basic appropriate component like carrier which are protecting the drug and enhancing the drug concentration in targeted tissue and reduced the rapid degradation or clearance of drug. The number of articles, review and research have been published on niosomes in the last one decade. The niosomes are carrier which show the several advantages for drug delivery. Niosomes are formed by non-ionic surfactant vesicles which are assembled by themselves. Niosomes carried the drug and release the drug on targeted site and it can be reduced side effect of drug and enhance the therapeutic effect on various disease.

Niosomes as vesicular carriers for delivery of proteins and biologicals

International Journal of Drug Delivery, 2011

Over the past several years, treatment of infectious diseases and immunization has undergone a paradigm shift. Stemming from the nanobiotechnology research, not only a large number of disease-specific biologicals have been developed, but also enormous efforts have been made to effectively deliver these biologicals. Niosomes are vesicular systems prepared from selfassembly of hydrated non-ionic surfactants. Opinions of the usefulness of niosomes in delivery of proteins and biologicals range from unsubstantiated optimism to undeserved pessimism. This article reviews the current deepening and widening of interest of niosomes in many scientific disciplines, and their application in medicine particularly for the delivery of proteins (insulin, cyclosporine, bacitracin, trypsin), vaccines and antigens (bovine serum albumin, antigen tetanus toxoid, haemagglutinin). This article also presents an overview of techniques of noisome preparation, characterization of niosomes and their applications.

Niosomes as a Potential Drug Delivery System

International Journal of Pharmaceutical Sciences Review and Research, 2021

A non-ionic vesicle dependent on surfactants is a niosome. Niosomes are mainly formed as an excipient by non-ionic surfactant and cholesterol incorporation. Various excipients can also be used. Niosomes have a greater penetrating potential than previous emulsion preparations. There are various methods of manufacturing niosomes like thin film hydration, microfluidization, sonication, bubble method to name a few. The fact that niosomes are amphiphillic molecules makes them a flexible carrier of drugs, as both hydrophilic and lipophillic drugs can be trapped. Applications of niosomes in the pharmaceutical industry are many, some of the most important ones being as cosmoceuticals, gene delivery carriers, carriers for vaccine delivery and also in medical imaging. The main object of this review the appliance of niosome technology is employed to treat variety of diseases, niosome have good opportunity in research and beneficial for researcher and pharma industries. As niosome is stable and...

Niosomes: A Unique Drug Delivery Tool

World Journal of Pharmacy and Pharmaceutical Sciences, 2014

Synthetic nonionic surfactants such as alkyl or dialkyl poly glycerol ether class when hydrated give niosomes. Niosomes are the drug carriers which provide substitute to liposomes and encapsulate the solutes in a way similar to liposomes. These may be unilamellar or multilamellar vesicles, present more in vitro stability and improved stability of drugs entrapped in comparison with the dosage forms which are conventional. [1] Niosomes can hold amphiphillic as well as lipophilic drugs and have the advantage of being biocompatible, biodegradable and non immunogenic over liposomes. Niosomes are used for targeted as well as controlled release for the treatment of many diseases including cancer, viral and other microbial diseases.

Niosomes as Promising Vehicle for Novel Drug Delivery System : Recent Review

2017

Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. This systemic review article deals with preparation methods, characterizations, factors affecting release kinetic, advantages, and applications of niosomes.