Metabolic activation of 2′, 3′-Didehydro-3′-Deoxythymidine (D4T) in isolated maternal and fetal peripheral blood mononuclear cells at term gestation (original) (raw)

The study examines the metabolic activation of 2',3'-Didehydro-3'-deoxythymidine (D4T) within isolated maternal and fetal peripheral blood mononuclear cells at term gestation. The authors aimed to understand the implications of D4T metabolism in the context of maternal-fetal health, particularly in the prevention of mother-to-child transmission of HIV. Their findings highlight the significance of D4T activation in both maternal and fetal cells, suggesting potential therapeutic applications and necessitating further investigation into the metabolic processing of antiretroviral drugs during pregnancy.