FRI0686 RELATIONSHIP Between Vitamin D Supplementation and Muscular Strength in Eldest Population. A Sistematic Review (original) (raw)
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Effect of Vitamin D Supplementation on Muscle Function in Elderly Individuals: A Meta-Analysis
The Egyptian Journal of Geriatrics and Gerontology, 2018
Background The changes in body composition and functions that occur in the ageing population include decreases in skeletal muscle mass, strength, and mobility. These decreases in muscle mass and strength are collectively called sarcopenia, which is associated with frailty and falls 1. The prevalence rates of sarcopenia are 5-13% and 11-50% in young-old and old-old individuals, respectively. These prevalence rates illustrate that decreases in muscle mass and strength constitute an important problem among elderly individuals. Early intervention may be helpful for limiting sarcopenia and preserving muscle mass and strength 2. Elderly individuals are susceptible to developing vitamin D deficiency due to various risk factors, such as diminished sunlight exposure, decreased skin thickness, impaired intestinal absorption, and reduced hydroxylation in the liver and kidneys. Decreased dietary intake and limited dietary sources of vitamin D also play important roles in vitamin D deficiency among elderly individuals [3. The decrease in vitamin D receptors that occurs with increasing age partly explains the age-related decrease in muscle function 4. These risk factors make vitamin D deficiency more
Nutrients, 2017
Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study (n = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1-SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = -2.56 (0.96); SQ4: -2.16 (1.06)) and women (SQ1: -1.10 (0.52); SQ4: -1.28 (0.50)) (all p ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (-0.40 (0.1)), (both p ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25...
Bone, 2007
Background: Vitamin D insufficiency is common in elderly adults, and leads to secondary hyperparathyroidism, bone loss, muscle weakness, and osteoporotic fractures. Objective: To evaluate the relation between vitamin D nutritional status and muscle function and muscle strength in women aged over 65 years. Methods: Fifty-four postmenopausal women from Buenos Aires (latitude 34° S), average age (X±DS) 71±4, were included in the study. Determinations of serum calcium, phosphate, 25 hydroxyvitamin D (25OHD), intact parathormone (iPTH) and calciuria / creatininuria ratio in 24-hour urine samples were performed. Muscle function was assessed by means of walking-speed test, standing balance, and sit-to-stand tests. Lower extremity muscle strength was determined using a manual dynamometer. Results: 25OHD levels ≥20ng/ml were found to be associated with better lower extremity muscle function and strength. Forty-six % of participants had 25OHD levels ≥20ng/ml. Women with 25OHD levels ≥20ng/ml scored higher on the muscle function tests (11.2±0.9 vs.10.0±2.1; p<0.003) and had stronger knee extensor (13.4±2.7 vs.11.6±2.5 Kg.; p<0.03) and hip abductor (8.3±2.7 vs. 7.3±3.1 Kg; p<0.04) muscles; strength of their hip flexors tended to be higher but did not reach significantly different values (17.0±3.3 vs. 15.4±2.8 Kg.; 0.1>p>0.05). Negative correlation was observed between iPTH and muscle function (r= -0.436; p<0.02). Conclusion: 25OHD levels ≥20ng/ml are needed for a better muscle function and strength. Assessing vitamin D nutritional status in adults aged ≥ 65 years would allow correcting hypovitaminosis D and improve muscle function and strength.
Clinical Interventions in Aging
Purpose: Maintaining skeletal muscle function throughout life is a crucial component of successful ageing. Adequate vitamin D status may be important in preserving muscle function. We aimed to determine the association between impaired muscle function and serum vitamin D status in community-dwelling older adults. Falls were explored as a secondary aim. Methods: Data were analyzed from adults aged ≥60 years, from Wave 6 of the English Longitudinal Study of Aging (ELSA). Handgrip strength (HGS) and the short physical performance battery (SPPB) were employed as measures of muscle strength and physical function, respectively. Serum 25-hydroxyvitamin D [25(OH)D] was assessed with concentration <30 nmol/L classed as vitamin D deficient. Results: The study comprised 4157 community-dwelling adults with a mean age of 69.8 (SD 6.9). Overall, 30.6% had low HGS and 12.7% had low SPPB (≤6). Participants with the lowest serum 25(OH)D (<30 nmol/L) had the highest prevalence of impaired muscle strength and performance (40.4% and 25.2%) compared with participants with levels ≥50 nmol/L (21.6% and 7.9%). Consistent with this, vitamin D deficiency (<30 nmol/L) was a significant determinant of low HGS (OR 1.44 [1.22, 1.71], p<0.001) and poor physical performance (OR 1.65 [1.31, 2.09], p<0.001) in the logistic regression models. Older adults partaking in regular moderate physical activity had significantly lower odds of impaired muscle strength (OR 0.65 [0.58, 0.79]) and physical function (OR 0.30 [0.24, 0.38]), p <0.001, respectively. Single or multiple falls (15.8% and 10.5% in past year) were not associated with vitamin D status. Conclusion: Vitamin D deficiency was associated with impaired muscle strength and performance in a large study of community-dwelling older people. It is generally accepted that vitamin D deficiency at the <30 nmol/L cutoff should be reversed to prevent bone disease, a strategy that may also protect skeletal muscle function in ageing.
The journal of nutrition, health & aging, 2011
Vitamin D insufficiency is common in elderly adults, and leads to secondary hyperparathyroidism, bone loss, muscle weakness, and osteoporotic fractures. To evaluate the relation between vitamin D nutritional status and muscle function and muscle strength in women aged over 65 years. Fifty-four postmenopausal women from Buenos Aires (latitude 34° S), average age (X±DS) 71±4, were included in the study. Determinations of serum calcium, phosphate, 25 hydroxyvitamin D (25OHD), intact parathormone (iPTH) and calciuria / creatininuria ratio in 24-hour urine samples were performed. Muscle function was assessed by means of walking-speed test, standing balance, and sit-to-stand tests. Lower extremity muscle strength was determined using a manual dynamometer. 25OHD levels ≥20 ng/ml were found to be associated with better lower extremity muscle function and strength. Forty- six % of participants had 25OHD levels ≥20 ng/ml. Women with 25OHD levels ≥20 ng/ml scored higher on the muscle function ...
Nutrition and Food Sciences Research
Background and Objectives: Sarcopenia is explained as the loss of muscle strength and muscle mass with aging‚ and is one of the major risk factors for metabolic diseases. Cross-sectional studies demonstrate that vitamin D is associated with sarcopenia in both men and women. The aim of this study was to investigate the effect of vitamin D supplement consumption on muscle strength, muscle function and body composition in middle-aged women. Materials and Methods: In this randomized double-blind placebo-controlled trial, 71 women aged 40-55 years old, with the serum 25(OH)-D <25 ng/ml, were divided in two groups randomly, and received a 1000 IU vitamin D tablet (n=37) or a placebo (n=34), daily for 12 weeks. At the beginning and at the end of the study, dietary intake, anthropometric indices, muscle strength and function, serum 25(OH)-D, physical activity level and sun exposure were assessed. Statistical analysis was performed with SPSS version 20. Results: A significant difference in serum 25(OH)-D was found between the intervention and placebo groups at the end of the study (P<0.001). In the vitamin D group, handgrip strength was improved, while hand grip strength (P=0.233) and knee extension strength (P=0.337) between the two groups did not differ significantly after 12 weeks. The mean of timed get up and go test, decreased significantly in the vitamin D group compared to the controls (P<0.001). Within the intervention group, body fat content decreased significantly after 12 weeks (P<0.001), but did not result a significant difference between the two groups (P=0.051). Conclusions: It seems in this vitamin D-deficient middle-aged women group, 1000 IU vitamin D consumption daily for 12 weeks resulted in improvement of muscle function and body composition, but had no significant effect on muscle strength.
European Journal of Clinical Nutrition, 2013
BACKGROUND/OBJECTIVES: Serum 25-hydroxyvitamin D (25(OH)D) status has been associated with muscle mass, strength and physical performance in healthy elderly people. Yet, in pre-frail and frail elderly people this association has not been studied. The objective of this study was to explore the association between vitamin D intake and serum 25(OH)D status with muscle mass, strength and physical performance in a pre-frail and frail elderly population. SUBJECTS/METHODS: This cross-sectional study included 127 pre-frail and frail elderly people in The Netherlands. Whole body and appendicular lean mass (ALM) (dual energy X-ray absorptiometry), leg strength (one repetition maximum), handgrip strength and physical performance (short physical performance battery) were measured, and blood samples were collected for the assessment of serum 25(OH)D status (liquid chromatography-tandem mass spectrometry). In addition, habitual dietary intake (3-day food records) and physical activity data (accelerometers) were collected. RESULTS: In total, 53% of the participants had a serum 25(OH)D level below 50 nmol/l. After adjustment for confounding factors, 25(OH)D status was associated with ALM (b ¼ 0.012, P ¼ 0.05) and with physical performance (b ¼ 0.020, Po0.05). Vitamin D intake was associated with physical performance (b ¼ 0.18, Po0.05) but not with ALM (P40.05). CONCLUSION: In this frail elderly population, 25(OH)D status is low and suggests a modest association with reduced ALM and impaired physical performance. In addition, vitamin D intake tended to be associated with impaired physical performance. Our findings highlight the need for well-designed intervention trials to assess the impact of vitamin D supplementation on 25(OH)D status, muscle mass and physical performance in pre-frail and frail elderly people.
Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2021
A B S T R A C TIntroductionOlder people tend to have decreased activity and intake of macronutrients andmicronutrients that are not in accordance with the body's needs. Research in 2017on elderly men and women at the Center for Family Compensation (PUSAKA) inCentral Jakarta showed that 80.2% of elderly people have vitamin D deficiency. Lowserum levels of vitamin D in the body are the initial risk of decreased muscle massand physical performance in old age. where there is a significant correlation betweenlow serum vitamin D levels in the body with sarcopenia and mortality. The purposeof this study was to determine the correlation of vitamin D levels with muscle mass,muscle strength and physical performance in the elderly community at RSMHPalembang. Methods This research is a study analytic observation with a cross-sectional approach that was carried out at the Integrated Geriatric Clinic InternalMedicine RSMH Palembang from November 2019 to November 2020. A sample of 34people age...
The Journal of Clinical Endocrinology & Metabolism, 2013
Context: Studies examining whether vitamin D supplementation increases muscle mass or musclespecific vitamin D receptor (VDR) concentration are lacking. Objective: To determine whether vitamin D 3 4000 IU/d alters muscle fiber cross-sectional area (FCSA) and intramyonuclear VDR concentration over 4 months. Design and Setting: Randomized, double-blind, placebo-controlled study in a single center. Participants: 21 mobility-limited women (aged Ն65 years) with serum 25-hydroxyvitamin D (25OHD) levels 22.5-60 nmol/L. Main Outcome Measures: Baseline and 4-month FCSA and intramyonuclear VDR were measured from vastus lateralis muscle cross-sections probed for muscle fiber type (I/IIa/IIx) and VDR using immunofluorescence. Results: At baseline, mean (ϮSD) age was 78Ϯ5 years; body mass index (BMI) was 27Ϯ5 kg/m 2 ; 25OHD was 46.3Ϯ9.5 nmol/L; and a short physical performance battery score was 7.95Ϯ1.57 out of 12. At 4 months, 25OHD level was 52.5Ϯ17.1 (placebo) vs. 80.0Ϯ11.5 nmol/L (VD; PϽ0.01) and change in 25OHD level was strongly associated with percent change in intramyonuclear VDR concentration independent of group (rϭ0.87, PϽ0.001). By treatment group, percent change in intramyonuclear VDR concentration was 7.8Ϯ18.2% (placebo) vs. 29.7Ϯ11.7% (VD; Pϭ0.03) with a more pronounced group difference in type II vs. I fibers. Percent change in total (type I/II) FCSA was-7.4Ϯ18.9% (placebo) vs. 10.6Ϯ20.0% (VD; Pϭ0.048). Conclusion: Vitamin D 3 supplementation increased intramyonuclear VDR concentration by 30% and increased muscle fiber size by 10% in older, mobility-limited, vitamin D-insufficient women. Further work is needed to determine whether the observed effect of vitamin D on fiber size is mediated by the VDR and to identify which signaling pathways are involved. L ow vitamin D status has been associated with reduced muscle mass, strength, and performance in older adults (1-5). Several intervention studies have reported that vitamin D supplementation increases appendicular muscle strength and improves physical function particularly in older women with low vitamin D status (6-9).
The effect of vitamin D on sarcopenia depends on the level of physical activity in older adults
Journal of Cachexia, Sarcopenia and Muscle, 2020
Objective Sarcopenia in older adults is closely related to vitamin D deficiency and reduced levels of physical activity, but little has been reported on the interaction between physical activity and the positive effects of vitamin D. The purpose of this study was to explore the interactive effect of vitamin D and physical activity on muscle mass and function through animal experiments and population surveys. Methods Male 4-week-old C57BL/6J mice were fed different purified diets: a vitamin D-deficient diet (with increased calcium and phosphorus to prevent the effects of abnormal mineral levels on muscle) or a 1,25-dihydroxyvitamin D3 (1,25D)-supplemented diet. After 24 weeks on the assigned diets, the mice were immobilized. The level of skeletal muscle atrophy in the mice was determined by grip strength, gastrocnemius (GA) muscle mass and muscle fiber cross-sectional area (CSA); additionally, the protein expression levels of FOXO3a and the E3 ubiquitin ligases MuRF1 and MAFbx were detected. A cross-sectional study included data from 4139 older adults (64.9% women, 67.9 ± 6.7 years) as part of a survey in Shenyang, Northeast China. The associations of serum 25(OH)D3 and physical activity with timed up and go test (TUG) performance, handgrip strength, calf circumference, and body muscle mass were assessed by a linear regression analysis that was adjusted for covariates. Results In activity-limited mice, vitamin D deficiency accelerated the decrease in GA muscle weight, muscle fiber CSA, and grip strength and increased the protein expression of MuRF1, MAFbx, and FOXO3a (all P < 0.05). In addition, 1,25D supplementation may inhibit the grip-strength reduction induced by limited activity (P = 0.069). Serum 25(OH)D3 and physical activity were linearly related to TUG time (P < 0.001) and handgrip strength (P < 0.05) after adjustment for sex, age, body mass index (BMI), education level, smoking status, and serum calcium level. Serum 25(OH)D3 and physical activity had interactive effects on TUG (P < 0.001) and handgrip strength (P < 0.05) but not calf circumference or body muscle mass in older adults. Conclusions The effect of vitamin D on muscle strength and physical performance depends on physical activity level in the elderly. It is recommended that older adults strive to avoid both physical inactivity and vitamin D deficiency. Because physical inactivity and vitamin D deficiency may exacerbate muscle atrophy, the biological mechanism may involve synergistic effects of vitamin D and physical activity on the promotion of muscle protein ubiquitination and degradation.