Multi - Parameter Optimization for Two-Phase Unit-Cell based Tissue Scaffolds (original) (raw)

Porous three-dimensional (3D) tissue scaffolds directly influence cell attachment, proliferation, and guidance of new tissue formation. Cells respond to a scaffold's architecture, mechanical properties, and transport properties. Given the number of design constraints, scaffold design must include multiple design parameters. Using a unit-cell based assembly approach, we introduce a method to account for multiple design parameters during scaffold assembly. This paper presents our method for integrating multiple parameters for unit-cell selection.