New challenges in nanotechnology: the use of dendrimers in drug administration (original) (raw)

A Comprehensive review on Dendrimers in current advanced Drug delivery

International Journal of Research in Pharmaceutical Sciences, 2020

In this particular review, it is been noted that Dendrimers are novel three-dimensional globular nano-polymeric structure; having multiple functional groups on the surface enhances their function. Synonymous terms for dendrimer include arborols and cascade molecules. The importance of dendrimers in a large variety of fields has been detected, where the various types of dendrimers helps in various fields of drug delivery with the different types of dendrimers with the generation. Hence the dendrimer gains more attention from researchers among various nano-materials. Convenient synthesis of the structure makes them as a good nano-material for drug delivery. In recent, dendrimers showed their activity in different drug delivery systems having properties like cancer targeting, anti-bacterial, ocular drug delivery, etc.. The future direction about the dendrimers are been discussed. The present review is focused on types of dendrimers like Polypropylene Imine dendrimer (PPI), Poly...

Dendrimers as versatile platform in drug delivery applications

European Journal of Pharmaceutics and Biopharmaceutics, 2009

About forty percent of newly developed drugs are rejected by the pharmaceutical industry and will never benefit a patient because of poor bioavailability due to low water solubility and/or cell membrane permeability. New delivery technologies could help to overcome this challenge. Nanostructures with uniform and well-defined particle size and shape are of eminent interest in biomedical applications because of their ability to cross cell membranes and to reduce the risk of premature clearance from the body. The high level of control over the dendritic architecture (size, branching density, surface functionality) makes dendrimers ideal carriers in these applications. Many commercial small molecule drugs with anticancer, anti-inflammatory, and antimicrobial activity have been successfully associated with dendrimers such as poly(amidoamine) (PAMAM), poly(propylene imine) (PPI or DAB) and poly(etherhydroxylamine) (PEHAM) dendrimers, either via physical interactions or through chemical bonding ('prodrug approach'). Targeted delivery is possible via targeting ligands conjugated to the dendrimer surface or via the enhanced permeability and retention (EPR) effect. The biocompatibility of dendrimers follows patterns known from other small particles. Cationic surfaces show cytotoxicity; however, derivatization with fatty acid or PEG chains, reducing the overall charge density and minimizing contact between cell surfaces and dendrimers, can reduce toxic effects.

A review of in vitro–in vivo investigations on dendrimers: the novel nanoscopic drug carriers

Nanomedicine-nanotechnology Biology and Medicine, 2006

Dendrimers have emerged as one of the most interesting themes for researchers as a result of their unique architecture and macromolecular characteristics. Several groups are involved in exploring their potential as versatile carriers in drug delivery. The use of dendrimers in drug delivery has been reviewed extensively. The increasing relevance of the potential of dendrimers in drug delivery emphasizes the need to explore the routes by which they can be administered. The present review focuses on dendrimer-mediated drug delivery based on various routes of administration, a topic that has received little attention in the available literature. With this focus in mind, we present a comprehensive exploration of the recent advances in the investigational aspects of these nanoscopic polymeric devices. Also included are some in vitro studies that present data suggestive of their possible application in different routes of administration. D

Dendrimers: Nanopharmaceuticals for Drug Delivery

2010

Dendrimers are new class of polymeric materials. It is generally described as a macromolecule, which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Dendrimers are highly branched, globular macromolecules with many arms emanating from a central core. The unique properties associated with these dendrimers such as uniform size, high degree of branching, water solubility, multivalency, well-defined molecular weight and available internal cavities make them attractive for biological and drug-delivery applications. Present review will have main focus on advantages, different synthesis strategies of dendrimers, types of dendrimers and recent studies on important applications of dendrimers.

Role of Dendrimers in Advanced Drug Delivery and Biomedical Applications: A Review

Experimental Oncology, 2018

Aim: Dendrimers dendritic structural design holds vast promises, predominantly for drug delivery, owing to their unique properties. Dendritic architecture is widespread topology found in nature and offers development of specific properties of chemical substances. Dendrimers are an ideal delivery vehicle candidate for open study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, bio-distribution, internalization, blood plasma retention time, and filtration. This article reviews role of dendrimers in advanced drug delivery and biomedical applications.

Dendrimers: Potential Drug Carrier For Novel Drug Delivery System

Asian Journal of Pharmaceutical Research and Development

Dendrimers are new effectiveness of polymeric substances. They are relatively branched, monodisperse macromolecules. Structural Advantages permit dendrimers to play a critical function inside the fields of nanotechnology, pharmaceutical, and medicinal chemistry. As a result in their precise behavior dendrimers are suitable for a wide variety of biomedical and commercial packages. The paper gives a quick evaluation of dendrimers’ physicochemical properties and their possible use in various regions of research, generation, and treatment.

DENDRIMER: NOVEL STRATEGIES FOR DRUG DELIVERY SYSTEM

The development of novel particulate systems with defined shapes and sizes is of prominent interest in certain therapeutic applications such as drug delivery, gene transfection, diagnostic and imaging. On controlling and designing optimized architectural design of dendrimers; their shape, size, branching pattern length/density, and their surface functionality, clearly discriminate these structures as inimitable and optimal hauler in those applications. Moderately modified dendrimers have been shown to act as nano-drugs adjacent to tumors, viruses and bacteria. Recent triumph in simplifying and optimizing the production of dendrimers make available a large variety of structures while simultaneously reducing the cost of their production. The reflections on biomedical applications of dendrimers given in this review clearly make obvious the impending of this new fourth major class of polymer structural design and undeniably prove the high expectation for the future of dendrimers.

RECENT PROGRESS OF DENDRIMERS IN DRUG DELIVERY FOR CANCER THERAPY Review Article

International Journal of Applied Pharmaceutics, 2018

With the recent advances of nanotechnology, dendrimers are emerging as a highly attractive class of drug delivery vectors for cancer therapy. Dendrimers are multifunctional smart Nanocarriers to deliver one or more therapeutic agent safely and selectively to cancer cells. The high level of control over the synthesis of dendritic architecture makes dendrimers a nearly perfect (spherical) nanocarrier for site-specific drug delivery. The presence of functional groups in the dendrimers exterior also permits the addition of other moieties that can actively target certain diseases which are now widely used as tumor targeting strategies. Drug encapsulation, solubilization and passive targeting also equally contribute to the therapeutic use of dendrimers. Dendrimers are ideal carrier vehicles on cytotoxicity, blood plasma retention time, biodistribution and tumor uptake. In this review we highlight the advantages of dendrimers over conventional chemotherapy, toxicity and its management, following anticancer drugs delivered by using dendrimers and recent advances in drug delivery by various types of dendrimers as well as its diagnostic applications.

Dendrimers and their Applications as Novel Drug Delivery Carriers

Journal of Applied Pharmaceutical Science

Dendrimers are novel synthetic polymeric systems having improved physical and chemical properties due to their unique three dimensional architecture. Dendrimers have a well defined size, shape, molecular weight and monodispersity. These are compatible with drug moieties as well as bioactive molecules like DNA, heparin and other polyanions. The nanoscopic size and recognition abilities make dendrimers as ideal building blocks for self-assembly and self-organization systems. The cavities inside the dendritic structure can be modified to incorporate hydrophobic and hydrophilic drugs. The terminal groups are modified to attach antibodies and bioactive substances for targeting purpose along with providing miscibility, reactivity and solubility. Currently, dendrimers are of great interest for delivering drug molecules via different routes as a nanocarrier. Toxicity problems associated with cationic dendrimers are overcome by PEGylation, which neutralizes the charge on them. Dendrimers possess suitable properties to establish itself as a potential carrier for delivery of therapeutic agents irrespective of certain synthetic and regulatory constraints. This review contains various structural aspects and properties of dendrimers along with their pharmaceutical application as a potential novel drug delivery carrier.