Microwave-Assisted Synthesis, in Silico Studies and in Vivo Evaluation for Antidiabetic Activity of New Brominated Pyrazoline Analogues (original) (raw)

2019

Abstract

Introduction: Pyrazolines have played crucial role in the drug discovery researches and have been used widely as an important pharmacophores or intermediet for synthesis of bioactive compounds. Objective: The aim of this work is to explore the potential of new brominated pyrazoline analogues as antidiabetic. Methods: Synthesis of brominated pyrazoline analogues have been conducted under microwave irradiation, in silico studies was performed using AutoDock 1.5.4 software packages and Nano scale MD Program 2.9, and the animal used in the in vivo evaluation is male albino mices ( Mus musculus L.). Result: The i n silico studies for antidiabetic activity showed that compound 3a is the most active compound and furthermore it can be developed as new active agents for antidiabetic. The in vivo evaluation showed that compound 3a have a good ability to increase the percentage of change in blood glucose level and weight loss prevention, decreasing of the drinking water and also decreasing of...

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