Vitamin D status in patients with nontraumatic transient loss of consciousness (literature review) (original) (raw)
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Turkish Archives of Pediatrics
The study aimed to compare vitamin D levels between children and adolescents with vasovagal syncope, syncope due to orthostatic hypotension, cardiac syncope, and healthy individuals and to investigate the correlations of 25(OH)D with main clinical parameters of syncope. Materials and Methods: This study involved 83 children aged 8-17 years with syncope: 40 with vasovagal syncope, 24 with syncope due to orthostatic hypotension, and 19 with cardiac syncope. There were 24 healthy volunteers in the control group. Data concerning active standing test, electrocardiography, echocardiography, elect roenc ephal ograp hy, and 24-hour Holter monitoring findings were collected. Serum vitamin D was evaluated by an enzyme-linked immunoassay technique test. Results: The mean levels of serum 25(OH)D were decreased in children with vasovagal syncope (18.8 ± 5.9 ng/mL), syncope due to orthostatic hypotension (19.9 ± 6.7 ng/mL), and cardiac syncope (20.6 ± 7.3 ng/mL) in comparing with the control group (30.9 ± 5.9 ng/mL; P < .001). In patients with syncope due to orthostatic hypotension, vitamin D deficiency was associated with a reduction in systolic blood pressure (r = 0.43) and diastolic blood pressure (r = 0.38) within the first minute, lower systolic blood pressure (r = 0.44) within the third minute of active orthostasis (P < .05). There were significant correlations of vitamin D deficiency with parameters of cardiac autonomic activity pNN50 (r = 0.49), total power (r = 0.39), and low frequency index (r = 0.35) in children with cardiac syncope (P < .05), while heart rate variability was not affected in patients with vasovagal syncope and syncope due to orthostatic hypotension (P > .05). Conclusion: Children and adolescents with vasovagal syncope, syncope due to orthostatic hypotension, as well as cardiac syncope had higher frequency of vitamin D deficiency than healthy pediatric controls. This provides a new approach to syncope management in pediatric population, requiring further studies.
Hypocalcemic Convulsion in a Six-Years-Old Child with Vitamin D Deficiency
Akademik Acil T P Dergisi, 2014
Nutritional rickets occurs more commonly in breastfed infants with rapid growth and limited exposure to sunlight. Hypocalcemic convulsions secondary to vitamin D deficiency occur largely in patients with rapid growth rates, such as children younger than 1 year and adolescents. Vitamin D deficiency seems to be an unrecognized and prevalent problem in school childhood. Whereas infants generally exhibit bony deformities, most school-aged children are asymptomatic. In this case, we present hypocalcemic convulsion in a 6-year-old boy with nutritional vitamin D deficiency in order to emphasize that hypocalcemia secondary to vitamin D deficiency can lead to convulsion in other children, as well as infants and adolescents.
The International journal of neuroscience, 2014
Several disorders, both systemic and those of the nervous system, have been linked with vitamin D deficiency. Neurological disorders with a vitamin D link include but are not limited to multiple sclerosis, Alzheimer and Parkinson disease, as well as cerebrovascular disorders. Epilepsy which is the second leading neurological disorder received much less attention. We review evidence supporting a link between vitamin D and epilepsy including those coming from ecological as well as interventional and animal studies. We also assess the literature on the interaction between antiepileptic drugs and vitamin D. Converging evidence indicates a role for vitamin D deficiency in the pathophysiology of epilepsy.
Evaluation of Vitamin D Status in Patients with Epilepsy
International journal of home science, 2016
Background: Patients with epilepsy face an even greater risk of vitamin D deficiency than healthy population, as seizures may interfere with their ability to move outdoors and remain active which limits the exposure to sunlight necessary for producing vitamin D. Objective: Correction of vitamin D deficiency is an issue of concern and attention in patients with epilepsy. The present study was undertaken to understand and analyze the effect of vitamin D deficiency in epilepsy patients. Methods: Epileptic subjects with an age range of 3 to <80 years of both gender, below poverty line category, physically active patients on anti-epileptic drug treatment regularly, attending epilepsy clinic of the Super Specialty Hospital Sri Venkateswara Institute of Medical Sciences (SVIMS), Tirupati were included in the study. Blood samples were collected from selected subjects after informed consent and their willingness to be a part of the study and samples were analysed for parathromone and 25(O...
Evaluation of vitamin D status in children with refractory epilepsy
Journal of Dr. Behcet Uz Children s Hospital, 2014
OBJECTIVE: Vitamin D deficiency has been implicated in children using antiepileptic drugs. Multiple antiepileptic drugs may increase the risk of vitamin D deficiency. The aim of this study is to evaluate the vitamin D status and risk factors for vitamin D deficiency in children with refractory epilepsy. METHODS: Forty children with refractory epilepsy seen in our tertiary pediatric neurology outpatient clinic were included and serum 25-hydroxy vitamin D, parathyroid hormone, calcium, phosphate and alkaline phosphatase were measured. Vitamin D deficiency was defined as 25-hydroxy vitamin D levels <20 ng/mL, and insufficiency between 21 and 29 ng/mL. Correlation between vitamin D levels and type of epilepsy (generalized or localization related), etiology of epilepsy (symptomatic vs idiopathic), body mass index, seizure frequency, number of antiepileptic drugs, type of antiepileptic drugs (old or new; enzyme inducing or not), presence of intellectual disability, ambulatory status an...
First seizure presentation in an elderly woman with primary vitamin D deficiency: a case report
Endocrine Abstracts, 2014
V itamin D insufficiency is common in older people and is associated with several disorders related to aging such as osteoporosis, which leads to a significantly increased risk of bone fractures. This deficiency is more common in Mediterranean countries than in Northern European countries. Hypocalcemic seizures resulting from vitamin D deficiency are rare in adults, and fractures caused by seizures without evidence of direct trauma have not yet been reported. We present an unusual case of secondary right radius fracture caused by hypocalcemic seizures in a 63year-old Turkish woman with primary vitamin D deficiency. After vitamin D supplementation, increased serum 25-hydroxy vitamin D and calcium levels and decreased parathormone levels were found. The seizures had not recurred. It is important to check for calcium levels in older patients who present with non-febrile seizures. When hypocalcemia was found serum 25-hydroxy vitamin D levels should be measured to find the underlying cause. V itamin D eksikli¤i yafll› insanlara s›k rastlanmaktad›r ve kemik k›r›k riskinin belirgin art›fl›na yol açan osteoporoz gibi ciddi rahats›zl›klarla iliflkilidir. Bu eksiklik Akdeniz ülkelerinde Kuzey Avrupa ülkelerinden daha yayg›nd›r. Vitamin D eksikli¤ine ba¤l› hipokalsemik nöbet eriflkinlerde nadirdir ve direkt travma olmadan nöbete ba¤l› k›r›k henüz rapor edilmemifltir. Primer vitamin D ek-sikli¤ine ba¤l› hipokalsemik nöbetin neden oldu¤u sa¤ Radius k›r›¤› olan 63 yafl›nda Türk kad›n olgu sunmaktay›z. Vitamin D replasman› sonras›, serum 25-hidroksi vitamin D düzeyi ve kalsiyum seviyesinde art›fl ve parathormon seviyesinde ise azalma görülmüfltür. Nöbet tekrarlamam›flt›r. Nonfebril nöbet ile gelen yafll› hastalarda kalsiyum seviyesinin kontrolü önemlidir. Hipokalsemi tespit edildi¤inde altta yatan nedeni bulmak için serum 25-hidroksi vitamin D düzeyi de bak›lmal›d›r.
Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study
Epilepsy & Behavior, 2012
There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D on seizure control. Here, we measured serum 25-hydroxy-vitamin D (25(OH)D) levels and normalized it by administration of vitamin D3 in 13 patients with pharmacoresistant epilepsy. To see if vitamin D3 has an impact on seizure frequency, we compared seizure numbers during a 90-day period before and after treatment onset. We found that seizure numbers significantly decreased upon vitamin D3 supplementation. Median seizure reduction was 40%. We conclude that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.
Neurological manifestation of Vitamin D deficiency
Indian Journal of Case Reports
Idiopathic intracranial hypertension, also known as pseudotumor cerebri, is a disorder with raised intracranial pressure, headache, papilledema, visual disturbances with a normal cerebrospinal fluid examination, and normal neuroimaging. It is rare in the pediatric population and may occur as a manifestation of underlying disorders. Vitamin D deficiency is a common deficiency in the pediatric age group. However, neurological manifestations are rare. Here, we present the case of a 5-year-old male child who presented with headache, vomiting, and hypertension; however, the neurological examination was normal but the neuroimaging was suggestive of pseudotumor cerebri. Appropriate investigations were done. The most likely cause of pseudotumor cerebri in this patient was the deficiency of Vitamin D. We have reported this case as pseudotumor cerebri is a rare neurological manifestation of Vitamin D deficiency.