Expression of p53 protein in Barrets esophagus and esophageal cancer. Experience of the Department of Pathology, IICS (original) (raw)
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Revista de gastroenterología de México
To correlate the expression of p53 and BCl-2 with the clinical outcome and anatomic location of the gastrointestinal stromal tumours (GIST). The GIST are the most common nonepithelial neoplasm of the gastrointestinal tract. In spite of the existence of a wide range of predictive factors, their clinical outcome is unpredictable. There are several studies that correlate the expression of p53 and Bcl-2 with the clinical outcome and anatomic location of the GIST. We obtained 19 cases from the archives of the Department of Pathology of the ABC Medical Center, in Mexico City. GIST were classified into risk groups according to the Fletcher et al. classification. We performed an immunohistochemestry panel including CD117, CD34, actin, desmin, P-S100, p53 and BCl-2 and correlated their expression to the risk group and anatomical site of the tumors. There was less expression of p53 in the gastric tumors (27%) than in small bowel tumors (100%). There was greater expression of p53 in the high-r...
¿Cuál es la relación que guarda la proteína p53 con el cáncer? En este texto trataremos esta íntima relación, basándonos en publicaciones realizadas por investigadores que poseen una larga trayectoria en el análisis oncológico y la investigación de la p53.
2013
Objetivo : Caracterizar clinicamente e histopatologicamente las lesiones palatinas producidas por tabaquismo invertido y determinar la expresion de la proteina p53 en dichas lesiones. Materiales y metodos : Usando un diseno clinico observacional, 18 fumadores invertidos (FI) fueron incluidos en el estudio. Como controles (GC) 17 individuos no fumadores fueron pareados por genero. Posterior al consentimiento informado, fue completada historia clinica y tomadas biopsias de las lesiones y mucosa sana. Fueron realizadas coloraciones de HE p= 0.117). Sin embargo, tanto la intensidad de la expresion, como la ubicacion suprabasal fue mayor en los FI ( p= 0,001 y p= 0,0001 respectiva mente). Conclusiones : FI fue fuertemente asociado a estomatitis nicotinica. No se observo displasia epitelial severa o carcinoma, sin embargo la expresion intensa y suprabasal de p53 sugiere una alteracion genetica importante y este podria ser un excelente marcador de progresion maligna en estas lesiones
Revista Información Científica , 2022
Introduction: esophageal cancer is a leading cause of cancer-related illness that has been described for two thousand years and currently set at the eighth place in incidence worldwide. Objective: to describe the clinical-histological features in patients with esophageal cancer at the Guido Valadares National Hospital in Timor-Leste. Method: an observational-descriptive and retrospective study was conducted in 106 patients with esophageal cancer related endoscopic and histological diagnosis. All of them attended in the Endoscopy Unit at the Gastroenterology service, from June 2016 to May 2021. Variables such as age group, sex and other risk factors like (clinical manifestations, the onset of symptom, location, endoscopic type and histological type) were analyzed. Results: esophageal cancer was more frequent in male aged 60 and older (65.1%). Smoking and alcohol intake were the predominant risk factors (64.2% and 57.5%, respectively). Most of cases were diagnosed between 3 and 6 months after the onset of symptoms, with dysphagia as the main reason for consultation (98.1%). From the endoscopic point of view, polypoid mass or vegetating lesions found in the middle third of the esophagus predominated (45.3%), with squamous cell carcinoma as the most frequent histological type. Conclusions: study of clinical-histological features in patients with esophageal cancer allows an adequate diagnostic approach to this illness, as well as the development of preventive health actions on the main risk factors identified.
[Barrett's esophagus with high grade dysplasia or intramucosal adenocarcinoma: EMR or ESD?]
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 2019
Barrett's esophagus (BE) is a relatively common clinical entity with an important impact on the quality of life of these patients. The incidence of this pathology has been increasing in recent years due to an increase in the occurrence of predisposing factors such as gastroesophageal reflux disease. BE carries an oncogenic potential with the development of dysplasia or esophageal adenocarcinoma. Thus, endoscopic surveillance is recommended to BE patients, aiming to detect neoplastic transformation in an early stage, enabling less invasive therapeutic options like endoscopic resection as the first line of therapy. One of the most controversial issues in the recent management of Barrett's esophagus complicated by a pre-neoplastic or early neoplastic lesion is the technique of endoscopic approach: endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD). This question is extremely important because a complete endoscopic resection (R0) regardless of the techn...