The protein kinase Dyrk1A regulates cell number during the development of the central nervous system (original) (raw)

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

salvador zamora martinez

2002

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Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

Ausma Rabe

Journal of Neuroscience Research, 2012

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The Lck Tyrosine Kinase Is Expressed in Brain Neurons

Remi Fagard

Journal of Neurochemistry, 2002

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Cell Biology and Signaling

Surjyadipta Bhattacharjee

Neuro-Oncology, 2011

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The Stress-activated Protein Kinases

Joseph Avruch

Annals of the New York Academy of Sciences, 1995

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Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

Monica Alvarez

Brain Research, 2003

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Protein Kinase D Regulates Trafficking of Dendritic Membrane Proteins in Developing Neurons

Santiago Quiroga

Journal of Neuroscience, 2008

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ERK implication in cell cycle regulation

Jacques Pouysségur

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007

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Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex

Kimiko Shimizu

Neuroscience Research, 2011

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The origins of cellular diversity in the mammalian central nervous system

Ronald McKay

Cell, 1989

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Participation of Src-kinase in Age Changes of the Brain Central Zone

Yavisheva Tatiana

Journal of Psychiatry and Psychiatric Disorders

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Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1

Priit Kogerman

Journal of Biological Chemistry, 2002

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Dynamic regulation of ERK2 nuclear translocation and mobility in living cells

Mario Dalla Costa

Journal of Cell Science, 2006

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PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus

Federica Marini

The EMBO Journal, 1994

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Common mechanisms regulating cell cortex properties during cell division and cell migration

Chantal Roubinet

Cytoskeleton, 2012

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Protein Kinase A in Cancer

Carla Mucignat

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Apoptosis is dispensable for the control of cell number during early brain morphogenesis

YOSHIFUMI YAMAGUCHI

Developmental Biology, 2010

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Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Srividya Swaminathan

bioRxiv (Cold Spring Harbor Laboratory), 2022

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DYRK1A: A master regulatory protein controlling brain growth

Yann Herault

Neurobiology of Disease, 2012

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Regulation of Axonal Transport by Protein Kinases

Giampietro Schiavo

Trends in Biochemical Sciences, 2015

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CHL1 negatively regulates the proliferation and neuronal differentiation of neural progenitor cells through activation of the ERK1/2 MAPK pathway

Melitta Schachner

Molecular and Cellular Neuroscience, 2011

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MEK Is a Key Regulator of Gliogenesis in the Developing Brain

Jian Zhong

Neuron, 2012

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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

NICOLA OREFICE

Acta Neuropathologica Communications, 2019

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Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue

Jan-Willem Taanman

PLoS ONE, 2011

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DLK1, delta-like 1 homolog (Drosophila), regulates tumor cell differentiation in vivo

Asma Begum

Cancer Letters, 2012

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Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

G. D'Arcangelo

Journal of Neuroscience, 2010

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Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase

Paul Mosset

Bioorganic & Medicinal Chemistry, 2021

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LRRK2 modulates neuronal vesicles cycle through protein interactions

Carla Perego

SpringerPlus, 2015

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Sequence of a rat cDNA encoding the ERK1-MAP kinase

S. Stabel

Gene, 1992

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Neural Precursor Cell Lines Promote Neurite Branching

Evan Snyder

International Journal of Neuroscience, 2009

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Cdk1 is sufficient to drive the mammalian cell cycle

David Santamaria

Nature, 2007

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The Receptor-like Protein-tyrosine Phosphatase DEP-1 Is Constitutively Associated with a 64-kDa Protein Serine/ Threonine Kinase

Kevin Mossie

Journal of Biological Chemistry, 1997

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Cellular and Molecular Biology Cellu la r a n d Molecul a r B io log

Taha Nazir

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Negative Regulation of dE2F1 by Cyclin-Dependent Kinases Controls Cell Cycle Timing

Tânia Reis

Cell, 2004

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Negative regulation of receptor tyrosine kinase signals

Maurizio Alimandi

FEBS Letters, 2001

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