Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura (original) (raw)

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Deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura. Editorial

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Deficiency of ADAMTS13 Causes Thrombotic Thrombocytopenic Purpura

2010

Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura

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Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

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Role of ADAMTS13 in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura

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Hematology-American Society Hematology Education Program, 2012

Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura

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Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

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Carboxyl Terminus of ADAMTS13 Directly Inhibits Platelet Aggregation and Ultra Large von Willebrand Factor String Formation Under Flow in a Free-Thiol–Dependent Manner

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Seminars in Thrombosis and Hemostasis, 2010

The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice

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Journal of thrombosis and haemostasis : JTH, 2014

Degradation of Platelet-von Willebrand Factor Complexes by Plasmin: An Alternative/Backup Mechanism to ADAMTS13

Anil Chauhan

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The function of ADAMTS13 in thrombogenesis in vivo: insights from mutant mice

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International Journal of Hematology, 2010

Enzymatically Active ADAMTS13 Variants Are Not Inhibited by Anti-ADAMTS13 Autoantibodies

Journal of Biological Chemistry, 2005

ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura

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ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model

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Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

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Inhibitory autoantibodies against ADAMTS-13 in patients with thrombotic thrombocytopenic purpura bind ADAMTS-13 protease and may accelerate its clearance in vivo

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The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation

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Conformational plasticity of ADAMTS13 in hemostasis and autoimmunity

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Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura

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Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders: a severely deficient activity is specific for thrombotic thrombocytopenic purpura

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Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura

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Thrombospondin1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro

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Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

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