Abstract 12449: Exercise Has a Disproportionate Role in the Pathogenesis of Non-Desmosomal Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (original) (raw)

Circulation, 2014

Abstract

Background: Exercise is associated with age-related penetrance and arrhythmic risk in carriers of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)-associated desmosomal mutations; however its role in the pathogenesis of nondesmosomal ARVD/C is uncertain. Methods: Eighty-two patients with ARVD/C (39 desmosomal mutation carriers, all index cases) were interviewed about regular physical activity from age 10. Intensity (MET-Hrs/year) and exercise duration prior to clinical presentation were compared between patients with desmosomal and nondesmosomal ARVD/C. Association of exercise history with age at clinical presentation, family history, right ventricular structural dysfunction, and arrhythmic course was assessed. Results: Nondesmosomal patients were more likely to be endurance athletes (100% vs. 69% desmosomal, p Conclusion: Exercise has a differential impact on development of ARVD/C among nondesmosomal patients who require higher exercise intensity for developing th...

Dr Henry E Iheanacho hasn't uploaded this paper.

Let Dr Henry know you want this paper to be uploaded.

Ask for this paper to be uploaded.