Available Online through BIOCHEMICAL EVALUATION OF HYPOGLYCEMIC ANTIOXIDANT POTENTIAL OF HERBAL EXTRACT STUDIED IN (STZ) STREPTOZOTOCIN INDUCED DIABETIC RAT (original) (raw)
Gmelina arborea may be the good remedy for the treatment of diabetes mellitus. In this study, the oral administration of Luffa acutancula and Gmelina arborea showed the hypoglycemic activity and it could exert a beneficial action against biochemical alterations caused by the streptozotocin. Diabetes mellitus is a disease that affects more than 100 million people and may attain about five times more subjects in the next 10 years. In the search for new compounds, and within the exploratioration of natural resources, the hypoglycemic effect of plants which are reputed antidiabetic. The present study is carried out to identify new potential antidiabetic compounds of Luffa acutancula and Gmelina arborea. In the present study the antioxidative potential of Luffa acutancula and Gmelina arborea was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude that Luffa acutancula and Gmelina arborea are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential. The probable mechanism by which Luffa acutancula and Gmelina arborea exerts its protective action against streptozotocininduced pancreatic metabolic alterations could be by the stimulation of pancreatic regeneration through an improved synthesis of protein or accelerated detoxification and exertion. Furthermore, comprehensive chemical and pharmacological research is required to reveal the mechanism of the anti-diabetic potential of Luffa acutancula and Gmelina arborea.
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