Antioxidant , Cytotoxic and Apoptotic Activities of Crude Extract of Alpinia purpurata on Cervical Cancer Cell Line T Research (original) (raw)

Alpinia purpurata (Vieill.) K. Schum belongs in the Zingiberaceae family and is a very popular garden plant in India, it possesses moderate antibacterial and anticancer activities. To study the antioxidant, cytotoxic and apoptotic activities of n-hexane leaf extract of A. purpurata; antioxidant activity was determined by measuring (i) the scavenging effect of plant extract against 2, 2-diphenyl-1picryl hydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonate (ABTS), hydroxyl radical scavenging, superoxide radical scavenging, nitric oxide radical scavenging, hydrogen peroxide radical scavenging, metal chelating activity and (ii) reducing power capacity and ferric reducing power (FRAP). Cytotoxicity was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) and acridine orange/ethidium bromide staining to assess the anticancer activity of the crude extract on HeLa cells. The antioxidant activity of the plant extract was found to be close...

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