Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Nanosilver Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study (original) (raw)
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A Comparative Study Between Conventional And Nanosilver Dressings In Patients With Diabetic Ulcer
A patient of diabetes mellitus is exposed to a number of complications of which Diabetic foot is a common condition. The surgeon is usually facing the problem of " Life and Leg ". With proper understanding of the disease and the new concepts in the management of Diabetic foot, it has been possible to save many limbs and lives.The aim of this study is to evaluate the effectiveness of Nano crystalline silver dressings in the management of diabetic foot ulcer. A prospective study of 54 cases of Diabetic foot ulcers belonging to Wagner's Grades 1 and 2, admitted and treated (from Sept 2015 to Sept 2017) in Siddhartha Medical College / Government General Hospital, Vijayawada, AP, India was done. They were randomly sorted into 2 groups and comparative study was done between conventional and Nano silver dressings.Nano silver dressings in the treatment of diabetic foot ulcers were found to be safe, effective, promote wound healing and epithelization, eliminate anaerobes and break microbial synergy more effectively than conventional dressing.
Polymers
Diabetic foot ulcers (DFUs) are one of the most prevalent complications associated with diabetes mellitus. DFUs are chronic injuries that often lead to non-traumatic lower extremity amputations, due to persistent infection and other ulcer-related side effects. Moreover, these complications represent a significant economic burden for the healthcare system, as expensive medical interventions are required. In addition to this, the clinical treatments that are currently available have only proven moderately effective, evidencing a great need to develop novel strategies for the improved treatment of DFUs. Hydrogels are three-dimensional systems that can be fabricated from natural and/or synthetic polymers. Due to their unique versatility, tunability, and hydrophilic properties, these materials have been extensively studied for different types of biomedical applications, including drug delivery and tissue engineering applications. Therefore, this review paper addresses the most recent adv...
Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review
Acta Biomaterialia, 2013
Diabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, offer protection from secondary infections, remove wound exudate and promote tissue regeneration. However, no existing dressing fulfills all the requirements associated with DFU treatment and the choice of the correct dressing depends on the wound type and stage, injury extension, patient condition and the tissues involved. Currently, there are different types of commercially available wound dressings that can be used for DFU treatment which differ on their application modes, materials, shape and on the methods employed for production. Dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations, processed in the form of films, foams, hydrocolloids and hydrogels. Moreover, wound dressings may be employed as medicated systems, through the delivery of healing enhancers and therapeutic substances (drugs, growth factors, peptides, stem cells and/or other bioactive substances). This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment. Special emphasis is given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.
A Prospective Study on Efficacy of Various Dressings in the Management of Diabetic Foot Ulcers
Diabetic foot ulcer is a historically important disease which has been managed in myriad ways over the ages. Dressings form an important aspect of the treatment protocol. Here efficacy some of the newer dressings-namely collagen, alginate, topical hydrogel were compared with that of the conventional saline dressing. The study was done over a period of 6 months from March to October 2016 among 100 consenting diabetic foot ulcer patients admitted to Govt.Rajaji Hospital, Madurai. It was found out that patients in the collagen group had faster development of granulation tissue, shorter hospital stay and overall better healing.
Systematic review and mixed treatment comparison: dressings to heal diabetic foot ulcers
Diabetologia, 2012
Aims/hypothesis Foot ulcers in people with diabetes are a common and serious global health issue. Dressings form a key part of ulcer treatment. Existing systematic reviews are limited by the lack of head-to-head comparisons of alternative dressings in a field where there are several different dressing options. We aimed to determine the relative effects of alternative wound dressings on the healing of diabetic foot ulcers. Methods This study was a systematic review involving Bayesian mixed treatment comparison. We included randomised controlled trials evaluating the effects on diabetic foot ulcer healing of one or more wound dressings. There were no restrictions based on language or publication status. Results Fifteen eligible studies, evaluating nine dressing types, were included. Ten direct treatment comparisons were made. Whilst there was increased healing associated with hydrogel and foam dressings compared with basic wound contact materials, these findings were based on data from small studies at unclear or high risk of bias. The mixed treatment comparison suggested that hydrocolloid-matrix dressings were associated with higher odds of ulcer healing than all other dressing types; there was a high degree of uncertainty around these estimates, which were deemed to be of very low quality. Conclusions/interpretation These findings summarise all available trial evidence regarding the use of dressings to heal diabetic foot ulcers. More expensive dressings may offer no advantages in terms of healing than cheaper basic dressings. In addition, evidence pointing to a difference in favour of 'advanced' dressing types over basic wound contact materials is of low or very low quality.
IOSR Journals , 2019
Diabetes is one of major global health problem. Of all known complications of diabetes, diabetic foot ulcers remain a major challenge to health sectors with increasing morbidity and mortality. According to WHO every 20 seconds a limb is being amputated as result of diabetes. Many researches is being done on management of diabetic foot ulcer. Biological dressing like collagen dressings are natural, non immunogenic, non pyrogenic, hypoallergenic and pain free. On topical application in wounds they create a physiological interface between the wound surface and environment. The present study is a comparative study between the collagen based dressing and normal saline dressing in healing diabetic foot ulcers with Wagner grading I & II in our hospital GMKMCH, Salem. Out of 50 patients studied over a period of 5 months from April 2019 to August 2019, collagen based dressing was proved superior to normal saline dressing in terms of wound healing and infection control in diabetic foot ulcers. Thorough surgical wound debridement followed by collagen based dressing with good glycemic control definitely a first line of management in treating diabetic foot ulcers.
A Narrative Review on Modern Wound Dressing for Diabetes Mellitus Wound
INTERNATIONAL JOURNAL OF CARE SCHOLARS
Introduction: Diabetic foot is a wide-ranging term for foot disorders includes infection, ulceration, or destruction of deep tissue due to peripheral neuropathy and ischemia from peripheral vascular disease. Wound dressings play a significant part in the treatment of diabetic foot ulcer (DFU). Modern wound dressing which is commonly known as the moist wound dressing can be better optional than the conservative one for the DFU. Aim: This study aimed to review the available articles on modern wound dressing for diabetes mellitus wound. Method: A total of six articles were reviewed and explained under the findings and discussion part of this study. The published articles from the year 2008 onwards are included in this narrative review. Result: Overall, it is evident that using of modern wound dressing can make sure excellent wound surroundings, avoid complications, improvement of quality of life of patients and aid the healing of DFU providing that the patient’s glycemic level is cont...
https://ijshr.com/IJSHR\_Vol.4\_Issue.4\_Oct2019/IJSHR\_Abstract.0010.html, 2019
Aim: The objective of this review was to assess the impact of different dressing methodologies on the outcomes of wound healing in diabetic foot ulcer (DFU) patients. Methods:Systematic review analysis was performed by using search engines, like PubMed, Science Direct, Google, and Google Scholar. We retrieved selected published articles based on our study criteria and included the suitable articles published till January 2019. The keywords used for the retrieval of studies are “Diabetes mellitus”, “Dressing methodology”, “Diabetic foot ulcer”, and “Wound healing.” After screening the abstracts of the retrieved articles, eligible full-text articles were chosen for systematic review analysis. Results: We found 17 eligible studies that contained 9 research articles, 7 randomized controlled trials (RCTs), and 1 random study. Conclusion: Honey dressing methodology seemed to be effective in the treatment and outcomes of wound healing of different grades of DFUs. However, the efficacy of the other dressing methodologies, involving biological material and herbal extracts, needs to be validated with a greater number of trials in different types of DFUs. Keywords: diabetic foot ulcers, wound healing outcome, dressing methods
Panacea Journal of Medical Sciences, 2023
Abstract Introduction: Diabetic Foot ulcer is a major disease-causing disability to many patients around the world. Treatment of diabetic foot ulcers (DFU), which is the most common reason for lower-extremity amputation, remains a serious healthcare problem. Aim: To compare the normal saline dressing with collagen dressing in diabetic foot ulcer treatment. Materials and Methods: This comparative study was conducted on 100 patients, randomised into 50 patients in each group, Normal saline dressing and Collage dressing. The ulcer was evaluated after every 3 days to reduce the size, formation of granulation tissue and epithelisation until the ulcer healed completely or up to 8 weeks, whichever is earlier. Results: In both, groups male patients were more than female, i.e. CG group with 60% and NS group with 66%. The mean wound size was 47.93 cm for CG and 45.45 cmfor the NS group. The mean percentage improvement of ulcer size (73.43% VS 54.50% in 5 week), presence of granulation tissue (90% VS 0% patients in1 week) and presence of epithelial tissue (74% VS 4% patients in 1 week) were significantly better in CG than in NS group. Conclusion: From the above study, the collagen dressing is superior compared to normal saline dressing in management of diabetic foot ulcers. Keywords: College dressing, Normal saline dressing, Diabetic foot, Ulcer, Diabetes