Host and risk factors for gestational trophoblastic disease: a hospital-based analysis from India (original) (raw)

Medical science monitor : international medical journal of experimental and clinical research, 2003

Abstract

BACKGROUND Gestational trophoblastic disease (GTD) adversely affects pregnancy by the development of Hydatidiform mole and placental site gestational tumor. GTD is a discrete pool of epidemiological and clinicopathological entities. Therefore, every geographical region should be studied separately. The Indian subcontinent is under-reported for this disease. This paper analyses the data from a large hospital. MATERIAL/METHODS 92 patients with GTD were analyzed in the period from 1995 to 1999. RESULTS The incidence of GTD was 1.31 per 1000 live births and one per 967 pregnancies irrespective of outcome. 93.5% of the patients had moderate to severe vaginal bleeding as presenting symptom, while routine antenatal ultrasonography revealed GTD in 6.5% completely asymptomatic patients. Among the major risk factors were age over 30 (p=6.3 x 10(-3), RR=2.7), previous abortion (p<0.001, RR=3.9) and multigravida (p=4.9 x 10(-6), RR=4.1). Early detection and treatment on established lines can...

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