The Effects of Probiotic Supplementation on Dyslipidemia (original) (raw)
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Probiotics and their effects in reduction hyperlipidemia
Plant Biotechnol Persa, 2020
Hyperlipidemia is a chronic condition but in many cases it may be reversed by a healthy diet and regular exercise. It is also associated to metabolic syndrome, diabetes, and obesity. Hyperlipidemia is known as one of the risk factors for coronary vessels disease, peripheral artery disease, and cardiac arrest. Drug-therapy is a usual method for treating hyperlipidemia. Consumption of probiotics may improve this problem and reduce the course of disease as well as its signs. The purpose of this review is to assess clinical evidences associating to role and effects of probiotics on the hl. Probiotics have greater influence on persons who suffer from high cholesterol. In the intestine, probiotics can bind to cholesterol and prevent its ingestion. Furthermore, they help in production of some biliary acids which play role in lipid and cholesterol metabolism. Some probiotics can produce short chain fatty acids that prevent formation of cholesterol in the liver. Probiotics are effective factors in reduction of hl
The use of probiotics for improving lipid profiles in dyslipidemic individuals: an overview protocol
Systematic reviews, 2018
Dyslipidemia is a major risk factor in triggering cardiovascular events, which can lead to the death of millions of people around the world. Thus, several pharmacological and non-pharmacological therapeutic strategies have been developed in recent decades with the objective of improving lipid profiles, including the use of probiotics. Therefore, the purpose of this protocol is to describe the steps that will guide the construction of an overview to demonstrate the scientific evidence of the efficacy of probiotics in improving the lipid profile of dyslipidemic individuals and to propose specific recommendations regarding their use. The search will be conducted in the following databases: MEDLINE/PubMed, EMBASE, PROSPERO, Cochrane Library, CINAHL, JBI Database of Systematic Reviews and Implementation Reports, Google Scholar, and CADTH. Reviewers will select systematic evaluations and data analyses from randomized clinical trials that evaluated the effects of probiotics on lipid profil...
The Administration of Probiotics against Hypercholesterolemia: A Systematic Review
Applied Sciences
Hypercholesterolemia is a key factor in the progression of atherosclerosis and cardiovascular disease (CVD). CVD is a significant public health concern with a high death rate. Some of the main factors linked to CVD include genetics and lifestyle. Dyslipidemia has been one of the factors related to the onset of several CVD-related diseases. Several clinicopathological studies have shown a correlation between high cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-c), and CVD development. Probiotics have received a lot of attention for various beneficial effects, especially their ability to reduce blood cholesterol in humans. Probiotics were shown in several investigations to affect hypercholesterolemia by influencing cholesterol biosynthesis. The current review focuses on the human dietary interventions with probiotics and their effects on CVD risk factors and hypercholesterolemia. The outcomes are debatable and consider various parameters such as probiotic str...
A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics
Scientia Pharmaceutica, 2019
Cardiovascular diseases (CVD) are the major health issue of modernized society with a high mortality rate. Lifestyle, genetic makeup, and diet are some of the major influencing factors associated with CVD. The dyslipidemia is one such factor related to the development of several CVD. Many studies proved that the consumption of probiotics confers several health benefits. Several studies reported the evaluation of the cholesterol-lowering ability of probiotics (probiotics that showed positive effect in vitro and in vivo studies) in human volunteers. The current review summarizes the outcomes of human studies on the cholesterol-lowering property of probiotics. Probiotic consumption significantly improved the health status of hypercholesteremic patients by reducing the low-density lipoprotein cholesterol, total cholesterol, triglyceride levels, and increased the high-density lipoprotein cholesterol. The probiotic supplementation improved the lipid profile of diabetic patients, and obese people as well. However, not all probiotic interventions are effective against dyslipidemia. The results are controversial and depend on several factors such as probiotic strain, dose, duration of the treatment, lifestyle changes, etc. This literature survey indorses additional studies on the cholesterol-lowering property of probiotics, which could help to reduce the risk of CVD and other dyslipidemia associated health issues.
Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases
Experimental diabetes research, 2012
Cardiovascular diseases are one of the major causes of deaths in adults in the western world. Elevated levels of certain blood lipids have been reported to be the principal cause of cardiovascular disease and other disabilities in developed countries. Several animal and clinical trials have shown a positive association between cholesterol levels and the risks of coronary heart disease. Current dietary strategies for the prevention of cardiovascular disease advocate adherence to low-fat/low-saturated-fat diets. Although there is no doubt that, in experimental conditions, low-fat diets offer an effective means of reducing blood cholesterol concentrations on a population basis, these appear to be less effective, largely due to poor compliance, attributed to low palatability and acceptability of these diets to the consumers. Due to the low consumer compliance, attempts have been made to identify other dietary components that can reduce blood cholesterol levels. Supplementation of diet w...
Potential of probiotics in hypercholesterolemia: A meta-analysis
Indian journal of public health
Human studies on the effects of probiotics on lowering blood cholesterol levels have not yielded conclusive results. A meta-analysis of randomized controlled trials evaluating the effect of probiotics on lipid profile was conducted. Articles were reviewed systematically from web search bases; PubMed, Cochrane Clinical Trial Registry. Those studies which were meeting the inclusion criteria-providing matching placebo, at least single blind for probiotics and placebo, providing mean and standard deviations and not involving the use of probiotics were selected. 14 studies from 12 randomized controlled trials were analyzed providing information of 606 normo/hypercholesterolemic patients using Review Manager 5.3 (The Cochrane Collaboration, Oxford, UK). The pooled mean net change for total cholesterol (TC) is -8.40 mg/dl (-13.63, -3.61), for low-density lipoprotein (LDL) is -6.63 mg/dl (-10.63, -2.63), for high-density-lipoprotein-cholesterol is 0.59 mg/dl (-0.92, 2.09), and for triglycer...
The Mechanism of Probiotics in Preventing the Risk of Hypercholesterolemia
Reviews in Agricultural Science
Probiotics are beneficial live microorganisms because they provide health benefits to the host after being consumed in sufficient amounts, primarily by increasing the proliferation of native digestive microflora. Hypercholesterolemia is a condition in which cholesterol serum concentration is elevated significantly (exceeds 200 mg/dL). Hypercholesterolemia is characterized by high plasma levels of low-density lipoprotein (LDL) and low plasma concentration of high-density lipoprotein (HDL). This review aims to examine the mechanism of action of probiotics in preventing the risk of hypercholesterolemia and reducing LDL cholesterol levels in the human body. The mechanism of cholesterol-lowering effect of probiotic bacteria can be classified into four basic principles such as 1) the conversion of cholesterol to coprostanol, 2) the deconjugation of cholesterol by probiotics' bile salt hydrolase enzyme, 3) the alteration of protein expression related to cholesterol synthesis, and 4) the production of Short Chain Fatty Acids (SCFA) by probiotics. Cholesterol converted to coprostanol is not absorbed by the small intestine and is directly excreted with the feces. The deconjugated cholesterol is easily precipitated and thus not absorbed by the small intestine. It also induces the assimilation of cholesterol into the probiotic membrane. Finally, the SCFAs, produced by probiotics fermentation within host digestive tract, can upregulate the synthesis of HDL apolipoprotein.
Probiotics as complementary therapy for hypercholesterolemia
Biology and …, 2009
The role of probiotic organisms as alternative or complementary therapy in combating large number of gastro intestinal disorders and their ability to enhance immune response attracts global attention. In addition, their therapeutic use towards cholesterol-lowering activities has further increased their applications as effective probiotics for humans as supplements in milk and yoghurt, since there are no other supplements for hypercholesterolemia, which is the crucial risk factor for cardiovascular diseases. Changes in dietary habits, stressful life and lack of physical activities are the precursors for increasing incidences of hypercholesterolemia and subsequently cardiovascular diseases. The present review focuses on some of the animal studies and clinical trials conducted with probiotic lactobacilli and bifidobacteria. This review may throw some light to prove the ability of these probiotics as a novel alternative or adjuvants to chemical drugs to help fight hypercholesterolemia.
The Hypocholesterolemic Effect of Probiotics in the Hyperlipidemic Hamster
2008
Hypercholesterolemia is a major risk factor for the development of atherosclerosis; a number of pharmacological and non-pharmacological (including dietary) approaches being employed to reduce it. Up until now, the trials to prove the hypocholesterolemic effect of probiotics have not been convincing. There are only few data suggesting that the supplementation of the diet with functional food products containing probiotic bacteria lower LDL-cholesterol (LDL-C) concentration in patients with moderately elevated cholesterol concentration in plasma. The aim of the present study was to evaluate in vivo the anti-atherosclerotic effect of a probiotic compound, containing the Lactobacillus plantarum bacteria, using an animal model of diet induced atherosclerosis, the hyperlipidemic hamster. Results show that this probiotic compound administration to hyperlipidemic hamsters induces: a significant decrease of the total serum cholesterol, a significant increase of the serum antioxidant potentia...
American Journal of Lifestyle Medicine, 2019
Background. Nutrition and probiotics supplementation are considered as nondrug strategies for the control of coronary artery disease (CAD). The aim of the present study was to investigate the interactive effects of probiotic supplementation and weight loss program on anthropometric and metabolic syndrome (MetS) indices in patients with CAD. Methods. A randomized, double-blind, placebo-controlled trial was performed in 44 overweight CAD patients. All the patients received weight loss program (5% to 10% of initial body weight) throughout the study course. The subjects were randomly assigned into intervention or placebo groups (n = 22, each) and received a probiotic or maltodextrin capsule/day, respectively, for 12 consecutive weeks. Anthropometric and MetS indices were assessed. Results. There was a significant decrease in total cholesterol (−30.7 ± 49.83 vs −5.9 ± 65 mmol/L, P = .043) and low-density lipoprotein cholesterol (−25.64 ± 51.7 vs −5.44 ± 70.1 mg/dL, P = .049) in the probi...