Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1 (original) (raw)

Nuclear Overexpression of NAD(P)H:Quinone Oxidoreductase 1 in Chinese Hamster Ovary Cells Increases the Cytotoxicity of Mitomycin C under Aerobic and Hypoxic Conditions

Helen Seow

Journal of Biological Chemistry, 2004

Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C

Paula Fracasso

Advances in Enzyme Regulation, 1985

Reductive Activation of Mitomycin C by NADH:Cytochrome b5 Reductase

Cancer Research, 1993

Reductive Activation of Mitomycin C by NADHrCytochromebs ReducÃase1

Thái Quí Hà

Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase

Proceedings of the National Academy of Sciences, 1996

Decreased NADPH:Cytochrome P-450 Reductase Activity and Impaired Drug Activation in a Mammalian Cell Line Resistant to Mitomycin C under Aerobic but not Hypoxie Conditions1

Ian Stratford

2000

Generation of Reactive Oxygen Radicals through Bioactivation of Mitomycin Antibiotics

Cancer Research, 1986

Reversal of Mitomycin C Resistance by Overexpression of Bioreductive Enzymes in Chinese Hamster Ovary Cells1

Helen Seow

Cancer Research

The Intracellular Location of NADH:Cytochrome b5 Reductase Modulates the Cytotoxicity of the Mitomycins to Chinese Hamster Ovary Cells

Journal of Biological Chemistry, 1998

Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells

Cancer research, 2001

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells

Neil Gibson

Cancer research, 1990

Disruption of normal cellular bioenergetics in Balb/c mice by mitomycin C

The British journal of cancer. Supplement

Molecular targeting of mitomycin C chemotherapy

TATSUNORI OKAMURA

… journal of cancer, 1997

Nuclear Localization of NADPH:Cytochromec(P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells

Molecular Pharmacology, 2004

Preferential kill of hypoxic EMT6 mammary tumor cells by the bioreductive alkylating agent porfiromycin

Advances in Enzyme Regulation, 1995

Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells

Molecular Pharmacology, 2004

Kinetics and mechanism of mitomycin C bioactivation by xanthine dehydrogenase under aerobic and hypoxic conditions

Cancer research, 1993

Differential cytotoxycity of daunomycin in tumor cells is related to glutathione dependent hydrogen peroxide metabo¬lism

Argante Bozzi, Roberto Strom

Adducts of Mitomycin C and DNA in EMT6 Mouse Mammary Tumor Cells: Effects of Hypoxia and Dicumarol on Adduct Patterns1

UnKnown DNA

Cellular approaches to bioreductive drug mechanisms

Bonnie Kuehl

Cancer and Metastasis Reviews, 1993

Regulatory network of mitomycin C action in human colon cancer cells

TATSUNORI OKAMURA

Cancer …, 1999

Differential cytotoxicity of daunomycin in tumour cells is related to glutathione-dependent hydrogen peroxide metabolism

Argante Bozzi, Roberto Strom

The Biochemical journal, 1981

Mitomycin C: Experience in the United States, with emphasis on gastric cancer

Philip Schein, MD DSc(hon)

Cancer Chemotherapy And Pharmacology, 1978

Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer

Kenneth O'Byrne

British journal of cancer, 2000

Mitochondrial cytochrome c oxidase as a target site for daunomycin in K-562 cells and heart tissue

Lefkothea Papadopoulou

Cancer research, 1993

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol

Biochemical Pharmacology, 2001

High mitomycin C concentration in tumour tissue can be achieved by isolated liver perfusion in rats

Andreas Marinelli

Cancer Chemotherapy and Pharmacology, 1991

Inhibition of DNA Cross-linking by Mitomycin C by Peroxidase-mediated Oxidation of Mitomycin C Hydroquinone

Journal of Biological Chemistry, 2001

Exploration of two methods for quantitative Mitomycin C measurement in tumor tissue in vitro and in vivo

Juan VÁSQUEZ

Biological Procedures Online, 2013

NAD(P)H:Quinone Oxidoreductase Gene Expression in Human Colon Carcinoma Cells: Characterization of a Mutation Which Modulates DT-Diaphorase Activity and Mitomycin Sensitivity1

Neil Gibson

1992

Redox activities of antitumor anthracyclines determined by microsomal oxygen consumption and assays for superoxide anion and hydroxyl radical generation

Shau Yen

Biochemical Pharmacology, 1986

Conjugation of Glutathione and Other Thiols with Bioreductively Activated Mitomycin C. Effect of Thiols on the Reductive Activation Rate

Mrinalni Sharma

Chemical Research in Toxicology, 1994