AB0950 EFFECT of Selective Serotonin Reuptake Inhibitors and Serotonin Norepinephrine Reuptake Inhibitors on Bone Mineral Density in Egyption Patients with Primary Fibromyalgia (original) (raw)
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Osteoporosis International, 2014
Sixty patients diagnosed with generalized anxiety disorder and treated with either paroxetine, sertraline, or citalopram for at least 12 months were enrolled in this study, and the bone mineral density (BMD) of the patients was compared with that of 40 healthy volunteers. Selective serotonin reuptake inhibitor (SSRI) therapy in generalized anxiety disorder was found to be related with decreased BMD values. Introduction The objectives of this study were to evaluate the effect of SSRI therapy on BMD in postmenopausal women diagnosed with generalized anxiety disorder (GAD) and to identify the effects of the duration of disease and treatment on risk factors for osteoporosis. Methods Sixty patients diagnosed with GAD and treated with paroxetine, sertraline, or citalopram from the SSRI group for at least 12 months were enrolled. Social demographic features, the Hamilton Anxiety Scale (HAS) results, and the Hamilton Depression Scale (HDS) scores of all the patients were assessed. The BMD of the patients was measured by dual-energy X-ray absorptiometry (DXA) at the femoral and lumbar regions. The patients were divided into three groups which are the paroxetine, sertraline, and citalopram groups. The BMD of the patients was compared with that of 40 healthy volunteers. Results The L2-L4, total lumbar vertebrae, femoral intertrochanteric, total femoral Z-scores, and femoral Ward's region T-scores of the treatment group were lower than the median T-and Z-scores of the control group (p<0.05). Of the treatment groups, the femoral neck, trochanteric and intertrochanteric T-and Z-scores, total femoral T-and Zscores, and femoral Ward's T-and Z-scores of the sertraline group were significantly lower than the BMD values measured at the identical regions in the paroxetine and citalopram groups (p<0.05).There was a significant negative correlation between the duration of treatment and the BMD values. Conclusion SSRI therapy in GAD was found to be related with decreased BMD values. Further randomized controlled studies are warranted to determine whether SSRI use is a risk
Bone turnover and hormonal perturbations in patients with fibromyalgia
Clinical and experimental rheumatology
Studies of bone turnover in fibromyalgia (FM) have, to date, shown conflicting results. Although most patients with FM are women, only a few investigations have paid attention to the changes of sex hormones in FM. Moreover, FM is often viewed as a stress related disorder, and abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have been found in FM. The aim of the study was to assess bone turnover using serum osteocalcin and CTx in patients with FM and study correlation between bone turnover parameters and parathormon and hormones of the HPA axis. A total of 81 subjects participated in this study: 41 healthy volunteers and 40 patients with FM. Serum osteocalcin, crosslaps (C-telopeptide: CTx), parathyroid hormone (PTH), testosterone, estrogen, prolactin, FSH, and LH were measured. The mean age of the study population was 49.5 (7.6) years (32-69) and the mean disease duration was 8.1 (12.0) years (4.5-30.7). No difference between patients and controls were observed in seru...
Bone Mineral Density and Depression in Premenopausal Women with Primary Fibromyalgia Syndrome
Turkish Journal of Rheumatology, 2010
Objective: Sedentary lifestyle, depression and lack of physical activity may lead to a decrease in bone mineral density (BMD) in patients with fibromyalgia syndrome (FMS). The aim of this study was to evaluate the role of FMS in the development of osteoporosis and the impact of depression on the BMD. Materials and Methods: Fifty premenopausal women with a diagnosis of FMS according to the American College of Rheumatology (ACR) criteria and 40 premenopausal healthy controls were included in the study. A structured form was prepared covering demographic characteristics of the subjects. The severity of pain, disease activity and depression level were evaluated by Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI), respectively. Lumbar spine and left femoral neck BMD values were determined by dual energy X-ray absorptiometry (DEXA). Results: There was no difference between patients and controls according to age, body mass index and duration of education (p>0.05). BMD values in the lumbar vertebrae were significantly lower in the FMS group than in the controls (p<0.05). The BMD score was not different between the patients with a depression score higher or lower than the cut-off point (p>0.05). There were no correlations among BMD, age, and BDI, VAS, and FIQ scores (p>0.05). Conclusion: We found that BMD of the lumbar vertebrae was lower in FMS patients than in the control group. We detected that depression has no significant impact on BMD. (Turk J Rheumatol 2010; 25: 105-9) Özet Amaç: Fibromiyaljili (FMS) hastalarda, sedanter yaşam tarzı, depresyon ve azalmış fiziksel aktivite kemik mineral yoğunluğunun (KMY) azalmasına yol açabilir. Çalışmamızın amacı; FMS'nin osteoporoz açısından risk faktörü olup olmadığını ve bu hastalarda depresyonun KMY'ye etkisini araştırmaktı. Yöntem ve Gereçler: ACR tanı kriterlerine göre FMS tanısı alan 50 premenopozal kadın hasta ve 40 sağlıklı premenopozal kadın kontrol çalışmaya alındı. Olgulara demografik özelliklerini içeren yapılandırılmış bir form dolduruldu. Ağrı şiddeti Görsel Analog Skala (GAS) ile, hastalık aktivitesi Fibromiyalji Etki Sorgulaması (FES) ve depresyon düzeyi Beck Depresyon Ölçeği (BDÖ) ile değerlendirildi. Hastalar BDÖ kesme puanına göre iki gruba ayrıldı. KMY lomber omurga ve femur boynundan dual enerji X-ray absorbsiyometri (DEXA) ile ölçüldü. Bulgular: Hastalar ile kontrol grubu arasında yaş, vücut kitle indeksi ve eğitim süresi açısından fark saptanmadı (p>0.05). Lomber bölge KMY değerleri FMS grubunda anlamlı derecede düşük bulundu (p<0.05). Depresyon skoru kesme puanının üstündeki hastalarda, kesme puanının altındaki hastalarla karşılaştırıldığında KMY farklı değildi (p>0.05). KMY ile yaş, Beck skoru, ağrı şiddeti ve FES skoru arasında anlamlı korelasyon yoktu (p>0.05). Sonuç: Fibromiyaljili hastalarda lomber bölgede KMY'i kontrollerden düşük bulduk. Bu hastalarda depresyonun KMY'i etkilemediğini tespit ettik. (Turk J Rheumatol 2010; 25: 105-9) Anahtar sözcükler: Fibromiyalji, kemik mineral yoğunluğu, depresyon Al›nd›¤› Tarih: 18.07.
The serotonin and the bone assessment
Journal of medicine and life, 2013
Lately, the in vitro and in vivo studies on serotonin metabolism pointed their influence in bone health. In addition, there are no particular recommendations in performing the serum serotonin assessment in order to evaluate the skeletal status. Aim. We aimed to correlate the bone turnover markers and lumbar bone mineral density (BMD) with serotonin. There is a cross-sectional study in Caucasian postmenopausal women. They were not diagnosed with carcinoid syndrome, or bone anomalies, and received no treatment (including antiresorptives). We performed the bone formation markers: serum alkaline phosphatase (AP), serum osteocalcin (OC), and the bone resorption marker: serum CrossLaps (CL). Serum serotonin (high-pressure liquid chromatography), as well as central DXA (GE Prodigy) were assessed. 191 women of 57.1 years mean age were grouped according to DXA (WHO criteria). The linear regression analysis between serum serotonin and CL was not statistically significant (SS), between seroton...