Primary bone lymphomas—Clinical cases and review of literature (original) (raw)

Primary Lymphoma of Bone -Case Report

International journal of science and research , 2024

Primary lymphoma of bone is a very rare condition. The current study presents case of primary bone lymphoma in a 46-yearold male who presented with pain in the right thigh. Xray images showed lytic lesion in the right distal femur. Following a pathological fracture, patient underwent amputation. Further immunohistochemistry studies were done and the final diagnosis was primary bone lymphoma , possibly diffuse large B cell lymphoma.(1)

Primary non-Hodgkin's lymphoma of bone. A clinicopathologic study

Cancer, 1994

A retrospective analysis of patients presenting with primary lymphoma of bone (PLB) was performed to determine clinical factors affecting prognosis in relation to histological subtype and treatment outcome. Data from 106 patients, presenting with a PLB between 1943 and 1996, were retrieved from the files of the Netherlands Committee on Bone Tumours and Leiden University Medical Centre. The lymphomas were reclassified according to the REAL and updated Kiel classification. The clinical presentation, survival and prognostic factors were investigated. Sixty patients had sufficient clinical information and adequate follow-up to be included in the study. All 33 PLB that could be immunophenotyped were of B cell origin. According to the REAL classification, most PLB were large (B) cell lymphomas (92%) and according to the Kiel classification 45% of the tumours were centroblastic multilobated. PLB presented most often in the long bones (48%), with Ann Arbor stage I (46%), II (16%), IV (16%) and unknown (20%). Stage IV disease was exclusively caused by the presence of multiple bone lesions. Notwithstanding the heterogeneous treatment, the 5year overall survival was 61%; 46% of patients were progression free at 5 years. Patients at presentation older than 60 had a worse overall survival (76% vs 37%, P ‫؍‬ 0.0002) and a worse progression-free period (58% vs 28%, P ‫؍‬ 0.0073). Patients with the immunoblastic subtype had a worse survival than the centroblastic mono/polymorphic subtype or the centroblastic multilobated subtype (P ‫؍‬ 0.015). Primary lymphoma of bone represents an uncommon bone tumour with a relatively homogeneous morphology and clinical behaviour. Compared to other aggressive lymphomas, PLB have a favourable prognosis.

Primary Lymphoma of Bone: A case report and brief review of literature

Clinical Case Reports and Reviews, 2017

Skeletal manifestations of Non-Hodgkin Lymphoma (NHL) is unusual, occurring in less than 5% of NHL cases; and primary non-Hodgkin lymphoma of bone (PLB) is rare, usually diffuse large B-cell lymphoma. PLB generally presents with localised bone pain, or, less frequently, soft tissue swelling. Pathological fractures, well documented in soft tissue sarcomas, are unusual in PLB. We report a case of polystotic PLB that presented with involvement of left anterior tibia (with pathologic facture) and left frontal skull.

Primary Bone Lymphomas: Retrospective Analysis of 42 Consecutive Cases

Acta Ortopédica Brasileira, 2018

Objective: It is difficult to define parameters for management and factors associated with primary bone lymphoma (PBL). This article presents the experience in a single institution with 42 patients with PBL over a 16-year period (2000-2016). Methods: Fifty-five patients were retrospectively evaluated, and forty-two were included (76.3%). Results: Median age at diagnosis was 51.5 years, and median follow-up was 102.7 months. One patient had HIV. Pain in the affected site was the most prevalent symptom. The average time between symptom onset and diagnosis was 5.4 months. The vertebrae were most affected (n=16, 33.3%). According to the International Prognostic Index Score (IPI), 64.3% of the patients were classified as having low-grade lymphoma and 25.7% as low-intermediate. The most common histology was diffuse large B cell lymphoma (DLBCL) (85.7%). Immunophenotyping was CD20 positive in 93.5% of patients, and 11 patients had pathological fracture. All patients received chemotherapy a...

Primary bone lymphoma: A retrospective analysis

International Journal of Oncology, 2006

The aim of this study was to retrospectively define those patients with unequivocal primary bone lymphoma presenting to the Sheffield Lymphoma Group and document patient and tumour characteristics and management strategies, and correlate these with survival. Thirty-seven patients were documented from a total of 3148 cases of non-Hodgkin's lymphoma seen over 34 years. There were 17 males and 20 females, with a mean age of 55.4 years (range, 27-78). Pain was the most commonly presented symptom (67.5%), and the pelvis was the most frequently presented site (21.3%). Grade 2 and diffuse large B cell lymphoma comprised the majority of histologies (78.7% and 70.3%, respectively). Treatment was most often with radiotherapy alone (41.8%) or combined with CHOP-like chemotherapy (37.9%). The overall response rate was 56.7%, and 5-and 10-year survival rates were 64.5% and 49.6%, respectively. Univariate analysis showed an age of <60 years and complete response to be favourable prognostic factors. There was a trend toward better survival with combined modality therapy involving CHOP-like chemotherapy. Bone lymphoma has a better survival than other extranodal lymphomas. Younger age and complete response are favourable predictive factors. Combined modality treatment is likely to be the treatment of choice but this remains to be confirmed in large prospective multicentre studies.

Primary bone lymphoma: single institution case series

Irish Journal of Medical Science, 2008

Background Primary bone lymphoma (PBL) is a rare condition and accounts for less than 2% of adult lymphomas and 3% of all primary bone malignancies. Because of the rarity of this disease, there is a lack of prospective randomised clinical trials and hence optimal treatment is uncertain. Aim We report on our experience of treating PBL over 20 years. Methods Using our hospital database, we identified all patients with PBL, their treatment, and long-term follow-up.

Primary and secondary bone lymphomas

Cancer treatment reviews, 2015

Recent studies have contributed to the enhancement of clinical and molecular knowledge on bone lymphomas, a group of rare malignancies with particular characteristics. Nevertheless, several questions remain unanswered and the level of evidence supporting some diagnostic and therapeutic decisions remains low. Currently, three different forms of bone lymphomas can be distinguished: the primary bone lymphoma, consisting of a single bone lesion with or without regional lymphadenopathies; the polyostotic lymphoma, consisting of multifocal disease exclusively involving the skeleton; and the disseminated lymphoma with secondary infiltration of the skeleton. The first two forms exhibit a good prognosis, requiring treatments similar to those commonly used for nodal lymphomas of the same category, but several issues regarding the role of surgery and local control of the disease, the sequence of treatment, radiation volumes and doses, management of pathological fractures and prevention of late...

Primary Bone Non-Hodgkin’s Lymphoma: A Literature Review

2021

Primary Bone Lymphoma (PBL) according to the World Health Organization (WHO) is a single skeletal lymphoma with or without lymph node involvement and multiple bone lesions without visceral or lymph node involvement. The etiopathogenesis of this disease remains unclear and requires further research. Literature search was done using search engines from Pubmed, Google Scholar, Cochrane Library, Web of Science, popular premier orthopedic journals (JBJS, BJJ, CORR, INJURY, ABJS, ActaOrthopedica, IJO) and general medical journals (JAMA, NEJM, Lancet) in the last 5 year, but relevant older articles were included. The diagnosis of PBL is confirmed by clinical examination, radiological support and biopsy. Standard management to date includes immunochemotherapy with or without radiotherapy, while operative measures are limited to biopsy sampling and stabilization of pathologic fractures or impending fractures with risks above intermediate. A good prognosis is found in PBL patients with Diffus...

Primary Bone Lymphoma: An Experience of a Regional Cancer Center from India

South Asian Journal of Cancer, 2020

Background Primary bone lymphoma (PBL) is a rare disease, representing <5% of all extranodal non-Hodgkin’s lymphomas (NHLs). The optimal treatment strategy is still unclear. Here, we report our institutional outcome analysis of patients diagnosed with PBL. Materials and Methods From 2007 to 2014, the medical records of 22 patients with PBL were reviewed. Analysis was done for symptom-, patient-, disease-, and treatment-related characteristics. All patients were treated with chemotherapy with or without radiotherapy. Treatment response and impact of different prognostic factors on clinical outcome were analyzed. Results The median age of presentation was 44 years (range: 18–70 years). A total of 19 (86.4%) patients were ≤60 years of age and 3 (13.6%) patients were >60 years. Out of all, 18 were males and 4 were females. Ann Arbor clinical staging at diagnosis was Stage I in 13 (59.1%), Stage II in 3 (13.6%), Stage III in 2 (9.1%), and Stage IV in 4 (18.2%) patients. Spine wa...