Keratomycosis: Some Epidemiological Data, Diagnosis and Drug Sensitivity (original) (raw)
2016, American Journal of Infectious Diseases and Microbiology
Purpose: The present study was undertaken to investigate the prevalence of mycotic keratitis and the profile of the fungi responsible in this region. Special attention was given to assess the prevalence of various species of Aspergillus, predisposing factors for keratomycosis and drug sensitivity. Methods: Corneal scraping samples from 148 cases of corneal ulcer and traumatic corneal infection with clinically suspicion of having fungal infections were examined microscopically and for culture. Minimum inhibitory concentration (MIC) of itraconazole and amphotericin-B were tested against the Aspergillus species isolates. Results: Aspergillus species were isolated in 26 (20.15%) cases and Aspergillus fumigatus was the predominant species isolated in 17 (65.38%) cases. This fungus was found to be sensitive to itraconazole with MIC of 0,125 -1 µg/ml. Conclusion: Aspergillus fumigatus is more common in mycotic keratitis, and itraconazole is effective against it. Vegetative trauma is the ma...
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