The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (original) (raw)

Epidemiology of gastro-oesophageal reflux disease: a systematic review

Gut, 2005

A systematic review of the epidemiology of gastro-oesophageal reflux disease (GORD) has been performed, applying strict criteria for quality of studies and the disease definition used. The prevalence and incidence of GORD was estimated from 15 studies which defined GORD as at least weekly heartburn and/or acid regurgitation and met criteria concerning sample size, response rate, and recall period. Data on factors associated with GORD were also evaluated. An approximate prevalence of 10-20% was identified for GORD, defined by at least weekly heartburn and/or acid regurgitation in the Western world while in Asia this was lower, at less than 5%. The incidence in the Western world was approximately 5 per 1000 person years. A number of potential risk factors (for example, an immediate family history and obesity) and comorbidities (for example, respiratory diseases and chest pain) associated with GORD were identified. Data reported in this systematic review can be interpreted with confidence as reflecting the epidemiology of ''true'' GORD. The disease is more common in the Western world than in Asia, and the low rate of incidence relative to prevalence reflects its chronicity. The small number of studies eligible for inclusion in this review highlights the need for global consensus on a symptom based definition of GORD.

Gastroesophageal reflux disease: epidemiological data, symptomatology and risk factors

Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i

Patients with gastroesophageal reflux disease (GERD), present a typical symptomatology with heartburn and regurgitations in about 80%. This study will assess the prevalence of gastroesophageal reflux disease and some demographic features of the study group. It will also be assessed the sensitivity and specificity of GERD Questionnaire and the risk factors of the disease. For the current study 426 patients were selected who were admitted to a tertiary gastroenterology-hepatology hospital in Athens, Greece, complaining about having the common symptoms of GERD (heartburn and regurgitations). The study period was January 2008-March 2011. Positive diagnosis has been based on personal history, clinical examination and by upper gastrointestinal endoscopy. Of 426 patients, 20 were excluded from the study. 150 (36.9%) were women and 256 (63.1%) men. The mean patient age was 48.77 years with SD 14.32 years. The age group with the highest frequency of GERD was the 40-59 years including 196 (48...