A Case of Methotrexate Intoxication Misdiagnosed as Crimean-Congo Hemorrhagic Fever (original) (raw)

Crimean-Congo hemorrhagic fever (CCHF) is a fatal zoonotic disease caused by a Nairovirus belonging to Bunyaviridae family [1]. Main routes of transmission to human are infected tick bites and direct exposure to blood and tissues of infected animals or other patients. After an incubation period of 1 to 7 days, a flu-like illness accompanying non-specific symptoms such as fever, chill, headache, myalgia, and digestive problems occurs. In severe cases, the primary symptoms followed by hemorrhagic manifestations including petechiae, ecchymosis, hematuria, and melena. Thrombocytopenia, leukopenia and elevated transaminase levels are the most frequent abnormal laboratory findings in CCHF patients [2].