Energetic aspects of the mitochondrial biogenesis (original) (raw)

The study explores the origins of energy required for mitochondrial biogenesis and integrity, presenting evidence that energy generated by mitochondria is not essential for their own formation or for the biogenesis of new mitochondria. Experiments conducted on wild-type and oxidative phosphorylation-deficient yeast strains reveal that mitochondrial respiratory components can form without the energetic output from the mitochondria themselves, suggesting cytosolic reactions can provide the necessary energy. Findings indicate that the synthesis of respiratory chain components can occur regardless of mitochondrial energy generation, challenging previous assumptions regarding the relationship between energy production and mitochondrial development.