Cerebrospinal fluid monoaminergic metabolites are elevated in adults with Down's syndrome (original) (raw)

1987, Annals of Neurology

Abstract

This article reports monoaminergic metabolite [homovanillic acid (HVA), ], values from the cerebrospinal fluid (CSF) of 27 wild baboons ( Papio hamadryas ) aged 40 to 140 months. Animals were either anubis, or anubis with hamadryas admixture; males of the latter subspecies generally have a reduced tendency to disperse from their natal groups. Overall, the values and interrelationships among the CSF monoamine metabolites resembled data reported from closely related, captive-housed animals. For example, age was significantly correlated with HVA concentrations (r ϭ Ϫ 60, p Ͻ .05), but not with the other metabolites. Notably, males characterized by hamadryas admixture had significantly higher concentrations of HVA, 5-HIAA, and MHPG (p Ͻ .05, respectively), a result possibly driven by differences in serotonergic activity. These data provide initial evidence that variation in central monoaminergic activity, as indicated by CSF monoamine metabolite concentrations, may reflect differences in behavior and life history that have taxonomic and, perhaps, evolutionary significance.

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References (43)

  1. Abegglen JJ (1984): On Socialization in Hamadryas Baboons. Cranbury, NJ, Associated University Presses
  2. Asberg M, Nordstrom P, Traskman-Bendz L (1986): Cere- brospinal fluid studies in suicide. An overview. Ann NY Acad Sci 9(Suppl 4):374-376
  3. Berman ME, Kavoussi RJ, Coccaro EF (1997): Neurotrans- mitter correlates of human aggression. In Stouff DM, Breiling J, Maser JD (eds), Handbook of Antisocial Behavior. New York, John Wiley and Sons, Inc., pp 305- 313
  4. Botchin MB, Kaplan JR, Manuck SB, Mann JJ (1993): Low versus high prolactin responders to fenfluramine chal- lenge: marker of behavioral differences in adult male cynomolgus macaques. Neuropsychopharmacol 9:93-99
  5. Bowers MB, Gerbode FA (1968): Relationship of monoamine metabolites in human cerebrospinal fluid to age. Nature 219:1256-1257
  6. Brett FL, Turner TR, Jolly CJ, Cauble RG (1982): Trapping baboons and vervet monkeys from wild, free-ranging populations. J Wildlife Manag 46:164-174
  7. Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK (1982): Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 139:741-746
  8. Clarke AS, Kammerer CM, George KP, Kupfer DJ, McKin- ney WT, Spence MA, Kraemer GW (1995): Evidence for heritability of biogenic amine levels in the cerebrospinal fluid of rhesus monkeys. Biol Psychiatry 38:572-577
  9. Clarke AS, Boinski S (1995): Temperament in nonhuman pri- mates. Am J Primatol 37(2): 103-126
  10. Cloninger CR (1994): Temperament and personality. Curr Opin Neurobiol 4:266-273
  11. Commissiong JW (1985): Monoamine metabolites: their rela- tionship and lack of relationship to monoaminergic neuronal activity. Biochem Pharmacol 34(8):1127-1131
  12. Gordon E, Perlow M, Oliver J, Ebert M, Kopin I (1975): Ori- gins of catecholamine metabolites in monkey cere- brospinal fluid. J Neurochem 25:347-349
  13. Hellriegel ET, D'Mello AP (1997): The effect of acute, chronic and chronic intermittent stress on the central noradren- ergic system. Pharmacol Biochem Behav 57(1-2):207-214
  14. Higley JD, Suomi SJ, Linnoila M (1991): CSF monoamine metabolite concentrations vary according to age, rear- ing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacol 103(4): 551-556
  15. Higley JD, Mehlman PT, Taub DM, Higley SB, Suomi SJ, Linnoila M, Vickers JH (1992): Cerebrospinal fluid monoamine and adrenal correlates of aggression in free- ranging rhesus monkeys. Arch Gen Psychiatry 49:436-441
  16. Jacobs MJ, Schloeder CA (1993): The Awash National Park Management Plan: Report Presented to the Ethiopian Wildlife Conservation Organization.
  17. Kaplan JR, Shively CA, Fontenot MB, Morgan TM, Howell SM, Manuck SB, Muldoon MF, Mann JJ (1994): Demon- stration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosom Med 56(6):479-484
  18. Kaplan JR, Fontenot MB, Berard J, Manuck SB, Mann JJ (1995): Delayed dispersal and elevated monoaminergic activity in free-ranging rhesus monkeys. Am J Primatol 35:29-234
  19. Knutson B, Wolkowitz OM, Cole SW, Chan TC, Moore EA, Johnson RC, Terpstra J, Turner RA, Reus VI (1998): Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 155(3): 373-379
  20. Kraemer GW, Clarke AS (1996): Social attachment, brain function, and aggression. Ann NY Acad Sci 20:794:121- 135
  21. Kruesi MJ, Swedo SE, Hamburger SD, Potter WZ, Rapoport JL (1988): Concentration gradient of CSF monoamine metabolites in children and adolescents. Biol Psychiatry 24(5):507-514
  22. Kummer H (1968): Social Organization of Hamadryas baboons. Chicago, University of Chicago Press Linnoila M, Virkkunen M, Roy A (1986): Biochemical aspects of aggression in man. Clin Neuropharmacol 9(Suppl 4):377-379
  23. Manuck SB, Flory JD, McCaffrey JM, Matthews KA, Mann JJ, Muldoon MF (1998): Aggression, impulsivity and cen- tral nervous system serotonergic responsivity in a non- patient sample. Neuropsychopharmacology 19:287-299
  24. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers J, Suomi SJ, Linnoila M (1994): Low CSF 5-HIAA concentrations and severe aggression and impaired impulsive control in nonhuman primates. Am J Psychi- atry 15(10):1485-1491
  25. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers J, Suomi SJ, Linnoila M (1995): Correlation of CSF 5-HIAA concentration with sociality and the tim- ing of emigration in free-ranging primates. Am J Psy- chiatry 152(6):907-913
  26. Mulder R (1992): The biology of personality. Aust NZ J Psy- chiatry 26:364-376
  27. Nagel U (1973): A comparison of anubis baboons, hama- dryas baboons, and their hybrids at a species border in Ethiopia. Folia Primat 19:104-165
  28. Nystrom PD (1992): Mating Success of Hamadryas, Anubis and Hybrid Male Baboons in a "Mixed" Social Group in the Awash National Park, Ethiopia. PhD dissertation, Washington University, St. Louis, MO
  29. Phillips-Conroy JE, Jolly CJ (1986): Changes in the structure of the baboon hybrid zone in the Awash National Park, Ethipia. Am J Phys Anthropol 71:337-349
  30. Phillips-Conroy JE, Jolly CJ (1988): Scheduling of dental eruption in wild and captive baboons. Am J Primatol 15:1-13
  31. Phillips-Conroy JE, Jolly CJ, Nystrom P, Hemmalin H (1992): Migration in male hamadryas baboons of the Awash National Park, Ethiopia. Int J Primatol 13:455-476
  32. Phillips-Conroy JE, Bergman TJ (In press): Quantitative assessment of occlusal wear and age estimation in Ethi- opian baboons. In Jolly CE, Whitehead P (eds), Old World Monkeys. Cambridge, UK, Cambridge Univer- sity Press
  33. Pusey AE, Packer C (1987): Dispersal and philopatry. In Smuts BB, Cheney DL, Seyfarth RM, Wrangham RW, Struhsaker TT (eds), Primate Societies. Chicago, IL, Uni- versity of Chicago Press, pp 250-266
  34. Raleigh MJ, Brammer GL, McGuire MT (1983): Male domi- nance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (Cerco- pithecus aethiops sabaeus). In KA Miczek (ed), Ethophar- macology: Primate Models of Neuropsychiatric Disorders. New York, Alan R. Liss, pp 185-198
  35. Raleigh MJ, Brammer GL, Ritvo ER, Geller E, McGuire MT, Yuwiler A (1986): Effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys. Psychopharmacol 90:503-508
  36. Raleigh MJ, Brammer GL, McGuire MT, Pollack DB, Yuwiler A (1992): Individual differences in basal cisternal cere- brospinal fluid 5-HIAA and HVA in monkeys. The effects of gender, age, physical characteristics, and matri- lineal influences. Neuropsychopharmacol 7:295-304
  37. Riachi NJ, Harik SI (1992): Monoamine oxidases of the brains and livers of macaque and cercopithecus mon- keys. Exp Neurol 115:212-217
  38. Scheinin M, Chang WH, Kirk KL, Linnoila M (1983): Simul- taneous determination of 3-methoxy-4-hydroxyphe- nylglycol, 5-hydroxyindoleacetic acid, and homovanil- lic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Anal Biochem 131(1):246-253
  39. Seifert WE, Foxx JF, Butler IJ (1980): Age effect on dopamine and serotonin metabolite levels in cerebrospinal fluid. Ann Neurol 8:38-42
  40. Shelton SE, Kalin NH, Gluck JP, Kereztury MF, Schneider VA, Lewis MH (1988): Effect of age on cisternal cere- brospinal fluid concentrations of monoamine metabo- lites in nonhuman primates. Neurochem Int 13:3353- 3357
  41. Tohgi H, Takahashi S, Abe T (1993): The effect of age on con- centrations of monoamines, amino acids, and their related substances in the cerebrospinal fluid. J Neural Transmission 5:215-226
  42. Young LJ, Winslow JT, Nilsen R, Insel TR (1997): Species dif- ferences in V1a receptor gene expression in monoga- mous and nonmonogamous voles: behavioral conse- quences. Behav Neurosci 11:599-605
  43. Zuckerman M (1991): Psychobiology of Personality. Cam- bridge, UK, Cambridge University Press