Effect of Insulin on Norepinephrine Overflow at Peripheral Sympathetic Nerve Endings in Young Spontaneously Hypertensive Rats (original) (raw)
1996, American Journal of Hypertension
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Insulin inhibits norepinephrine overflow from peripheral sympathetic nerve ending
Biochemical and Biophysical Research Communications, 1992
;The effectsof insulin on peripheral nervous system are unknown. We therefore studied the effects of insulin on sympathetic nerve activity in isolated mesenteric arteries of Sprague-Dawley rats. The overflow of norepinephrine (NE) by electrical stimulation was used as the index of sympathetic nervous system activity. Insulin (0.5 to 1 U/I) decreased the NE release in a dose-dependent fashion. This inhibitory effect was, however, reversed by either 5x1 Om5 M cocaine or 5x1 O-4 M ouabain treatment. Thus, we postulate that insulin attenuates NE overflow from peripheral sympathetic nerve endings, probably due to enhanced NE reuptake.
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