Development of a Topical Phytosomal Gel of Woodfordia Fruticosa (original) (raw)

2015

Abstract

Woodfordia fruticosa (Family-Lythraceae) is an important traditional medicinal plant. Scientific investigations reported antimicrobial, antiinflammatory, hepatoprotective, analgesic, wound healing and antifertility activity. Phytosome technology has proved to be beneficial in providing better absorption and bioavailability of polar biomolecules over conventional herbal extracts. The aim of the present study was to prepare and evaluate topical phytosomal gel of woodfordia fruticosa extract (WFE). Dried flowers of the plant were subjected to soxhlation using 80% methanol. The extract was complexed with soyalecithin in various drug:lipid ratios of 1:1, 1:2, 1:3, 1:4 and 1:5. Phytosomal complex of WFE was prepared by Ethanol method and Reflux method. All formulations were evaluated for vesicle formation, % yield, Entrapment efficiency and invitro drug release studies. Drug: lipid ratio of 1:3(E3) was suitable as it resulted in greater Entrapment efficiency of 89.15% & invitro drug relea...

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