Determination of Biochemical and Histological Parameters of Alcohol Administration in Wistar Rats (original) (raw)

Animal model development of alcohol administration in rats is of crucial importance as it gives indirect information to effects of alcohol in humans. An indirect assessment of this would be the biochemical and histological data that could arise from such experiments. 20 Male Wistar rats weighing (63.50±3.79 g), were divided into four groups (consisting 15 treated animals and 5 control animals) and administered with varying concentrations of ethanol (5% 15% and 40%) via intragastric intubation for a period of 28 days. Probic evaluations, liver biochemical enzymes and alteration in histology profile of gastrointestinal tract (GIT) and viscera organs (namely the liver, kidney, heart and lungs) were determined after experimental duration. At 40% ethanol administration, the rats showed biochemically significant decrease in serum gamma glutamyl transferase (GGT), serum aspartate (AST) and Alanine amino transferase (ALT) when compared to normal study while 5% and 15% ethanol administered r...