Neurofilament Phosphorylation is Increased in Ventral Horn Neurons of Neonatal Rat Spinal Cord Exposed to Cerebrospinal Fluid from patients with Amyotrophic Lateral Sclerosis (original) (raw)

This research investigates the effects of cerebrospinal fluid (CSF) from patients with Amyotrophic Lateral Sclerosis (ALS) on neurofilament phosphorylation in motor neurons. Using a rat model, CSF samples from ALS and non-ALS patients were administered to neonatal rat spinal cords, leading to a significant increase in phosphor-NF labeling in ventral horn neurons. This finding suggests that circulating factors in ALS patient CSF induce neurodegenerative changes in motor neurons, highlighting the potential role of CSF in the pathology of ALS.