Inhaled Ambient Particulate Matter and Lung Health Burden (original) (raw)
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Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century
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Air pollution is a severe threat to public health globally, affecting everyone in developed and developing countries alike. Among different air pollutants, particulate matter (PM), particularly combustion-produced fine PM (PM2.5) has been shown to play a major role in inducing various adverse health effects. Strong associations have been demonstrated by epidemiological and toxicological studies between increases in PM2.5 concentrations and premature mortality, cardiopulmonary diseases, asthma and allergic sensitization, and lung cancer. The mechanisms of PM-induced toxicological effects are related to their size, chemical composition, lung clearance and retention, cellular oxidative stress responses and pro-inflammatory effects locally and systemically. Particles in the ultrafine range (<100 nm), although they have the highest number counts, surface area and organic chemical content, are often overlooked due to insufficient monitoring and risk assessment. Yet, ample studies have ...
Frontiers in Sustainable Cities, 2021
Nanoparticles (NPs) are receiving an increasing attention from many scientific communities due to their strong influence on human health. NPs are an important marker of air pollution caused by a variety of natural and anthropogenic sources. Due to their ultrafine size, they can be suspended in the atmosphere for a long time and can thus travel larger distances and cause several health issues after exposure. A variety of NPs that are found in indoor and outdoor settings cause respiratory and cardiovascular diseases. Exposure to NPs through active and passive smoking and household and occupational subjection is reported with thick septum, shortness of breath, and a high level of interleukin protein and tumour necrosis factor (TNF-α) that cause tumour generation in the exposed population. This comprehensive review summarises NPs' source, exposure, and impact on different organ systems. Respiratory models (experimental and computational) used to determine the particle's depositi...
Environmental Health Perspectives, 2012
Positive associations between airborne particulate matter (PM) and respiratory health have been observed in epidemiological studies (Brunekreef and Holgate 2002; Pope and Dockery 2006). In most studies, effects were linked to PM 10 and PM 2.5 (particulate matter < 10 µm and 2.5 µm in aero dynamic diameter, respectively). Fewer studies have reported health effects associated with exposure to coarse (PM 2.5-10 ; Brunekreef and Forsberg 2005) and ultrafine (PM 0.1 ; Ibald-Mulli et al. 2002) particles. Depending on sources, there is a significant hetero geneity in PM composition, which is reflected in in vitro and in vivo toxicological studies (Valavanidis et al. 2008). Current knowledge does not allow precise quantifi ca tion of the health effects of individual PM components or of PM emissions from different sources [Brunekreef 2010; World Health Organization (WHO) 2007], although various PM charac teris tics, such as surface area of particles, transition metal content, surface
Atmospheric Environment, 2009
A wide range of environmental particulate matter (PM) both indoor and outdoor and consisting of natural and anthropogenic PM was collected by high volume air filters, electrostatic precipitation, and thermophoretic precipitation directly onto transmission electron microscope (TEM) coated grid platforms. These collected PM have been systematically characterized by TEM, energy-dispersive X-ray spectrometry (EDS) and scanning electron microscopy (SEM). In the El Paso, TX, USA/Juarez, Mexico metroplex 93% of outdoor PM 1 is crystalline while 40% of PM 1 is carbonaceous soot (including multiwall carbon nanotubes (MWCNTs) and multiconcentric fullerenes) PM. Multiply-replicated cytotoxicity (in vitro) assays utilizing a human epithelial (lung model) cell line (A549) consistently demonstrated varying degrees of cell death for essentially all PM which was characterized as aggregates of nanoparticulates or primary nanoparticles. Cytokine release was detected for Fe 2 O 3 , chrysotile asbestos, BC, and MWCNT PM while reactive oxygen species (ROS) production has been detected for Fe 2 O 3 , asbestos, BC, and MWCNT aggregate PM as well as natural gas combustion PM. Nanoparticulate materials in the indoor and outdoor environments appear to be variously cytotoxic, especially carbonaceous nano-PM such as multiwall carbon nanotubes, black carbon, and soot nano-PM produced by natural gas combustion.
BioMed Research International, 2013
Epidemiological and clinical studies have linked exposure to particulate matter (PM) to adverse health effects, which may be registered as increased mortality and morbidity from various cardiopulmonary diseases. Despite the evidence relating PM to health effects, the physiological, cellular, and molecular mechanisms causing such effects are still not fully characterized. Two main approaches are used to elucidate the mechanisms of toxicity. One is the use ofin vivoexperimental models, where various effects of PM on respiratory, cardiovascular, and nervous systems can be evaluated. To more closely examine the molecular and cellular mechanisms behind the different physiological effects, the use of variousin vitromodels has proven to be valuable. In the present review, we discuss the current advances on the toxicology of particulate matter and nanoparticles based on these techniques.
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The biomonitoring of nanoparticles in patients’ broncho-alveolar lavages (BAL) could allow getting insights into the role of inhaled biopersistent nanoparticles in the etiology/development of some respiratory diseases. Our objective was to investigate the relationship between the biomonitoring of nanoparticles in BAL, interstitial lung diseases and occupational exposure to these particles released unintentionally. We analyzed data from a cohort of 100 patients suffering from lung diseases (NanoPI clinical trial, ClinicalTrials.gov Identifier: NCT02549248) and observed that most of the patients showed a high probability of exposure to airborne unintentionally released nanoparticles (>50%), suggesting a potential role of inhaled nanoparticles in lung physiopathology. Depending on the respiratory disease, the amount of patients likely exposed to unintentionally released nanoparticles was variable (e.g., from 88% for idiopathic pulmonary fibrosis to 54% for sarcoidosis). These findin...
Journal of Materials Science-materials in Medicine, 2004
Airborne aggregates of nanoparticulates were collected on carbon/form-coated, 100-mesh Ni TEM grids in a thermal precipitator and observed in an analytical TEM utilizing a BF-SAED-DF-EDS characterization protocol to identify the nanocrystalline or nanoparticulate components, especially their degree of crystallinity, size, structural/morphologic features, and chemistries. Reference aggregates of TiO2 rutile and anatase as well as Si3N4 nanoparticles were used to establish these characterization protocols, which were applied to several hundred individual particulates: homogeneous aggregates of carbonaceous/diesel particulate matter, complex mixtures of carbonaceous matter, including carbon nanocrystals, and inorganic nanocrystals; and heterogeneous, nanocrystal/nanoparticulate aggregates. Most airborne particulates were aggregates ranging in aerodynamic diameters from a few nanometers to a few microns; containing as few as 2 nanocrystals to several thousand nanocrystals or nanoparticulates such as carbonaceous spherules arranged in complex branched homogeneous aggregates composing diesel exhaust, with spherule diameters ranging from 10 to 30 nm. The potential for ultrafine airborne aggregates to fragment into hundreds or thousands of nanoparticulate components in human airways and act as toxic agents in deep lung tissue is demonstrated.
The Journal of allergy and clinical immunology, 2016
Ultrafine particles (UFPs) are airborne particulates of less than 100 nm in aerodynamic diameter. Examples of UFPs are diesel exhaust particles, products of cooking, heating, and wood burning in indoor environments, and, more recently, products generated through the use of nanotechnology. Studies have shown that ambient UFPs have detrimental effects on both the cardiovascular and respiratory systems, including a higher incidence of atherosclerosis and exacerbation rate of asthma. UFPs have been found to alter in vitro and in vivo responses of the immune system to allergens and can also play a role in allergen sensitization. The inflammatory properties of UFPs can be mediated by a number of different mechanisms, including the ability to produce reactive oxygen species, leading to the generation of proinflammatory cytokines and airway inflammation. In addition, because of their small size, UFPs also have unique distribution characteristics in the respiratory tree and circulation and m...